The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity

Dipeptidyl peptidase (DPP)-4 is responsible for the degradation of several peptides that contain an alanine or proline at the penultimate position or position P1. DPP-4 inhibitors (DPP-4is) have protective effects against type-2 diabetes and several metabolic disorders. In the present study, we exam...

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Bibliographic Details
Published in:PloS one 2013-05, Vol.8 (5), p.e63626
Main Authors: Shimasaki, Takanobu, Masaki, Takayuki, Mitsutomi, Kimihiko, Ueno, Daisuke, Gotoh, Koro, Chiba, Seiichi, Kakuma, Tetsuya, Yoshimatsu, Hironobu
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose tissue (brown)
Adipose Tissue, Brown - drug effects
Adipose Tissue, Brown - metabolism
Adipose Tissue, White - drug effects
Adipose Tissue, White - metabolism
Alanine
Animals
Biology
Body fat
Diabetes
Diabetes mellitus
Diet
Dietary Fats - adverse effects
Dipeptidyl-peptidase IV
Dipeptidyl-Peptidase IV Inhibitors - pharmacology
Drug dosages
Endocrinology
Fatty acids
Food
Food intake
Gene expression
Glucagon
Glucagon-like peptide 1
Humidity
Hypoglycemic agents
Hypothalamus
Insulin
Internal medicine
Ion Channels - metabolism
Laboratory animals
Male
Medicine
Melanocortin
Melanocyte stimulating hormone
Metabolic disorders
Metabolism
Mice
Mice, Inbred C57BL
Mitochondrial Proteins - metabolism
Muscles
Musculoskeletal system
Obesity
Obesity - metabolism
Peptidase
Peptides
Peroxisome proliferator-activated receptors
Physiology
PPAR gamma - metabolism
Proline
Proopiomelanocortin
Proteins
Pyrazines - pharmacology
Rodents
Serum levels
Sitagliptin Phosphate
Skeletal muscle
Studies
Thermogenesis
Triazoles - pharmacology
Type 2 diabetes
Uncoupling Protein 1
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Summary:Dipeptidyl peptidase (DPP)-4 is responsible for the degradation of several peptides that contain an alanine or proline at the penultimate position or position P1. DPP-4 inhibitors (DPP-4is) have protective effects against type-2 diabetes and several metabolic disorders. In the present study, we examined the effects of des-fluoro-sitagliptin (DFS), a DDP-4i, on body adiposity and levels of peroxisome proliferator-activated receptor (PPAR)-α, PPAR-γ coactivator-1 (PGC-1), and uncoupling proteins (UCPs) in mice with diet-induced obesity. Treatment with DFS dose-dependently decreased the weight of white adipose tissue and serum levels of glucose, compared with controls, without influencing food intake (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0063626