Abnormal baseline brain activity in non-depressed Parkinson's disease and depressed Parkinson's disease: a resting-state functional magnetic resonance imaging study

Depression is the most common psychiatric disorder observed in Parkinson's disease (PD) patients, however the neural contribution to the high rate of depression in the PD group is still unclear. In this study, we used resting-state functional magnetic resonance imaging (fMRI) to investigate the...

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Bibliographic Details
Published in:PloS one 2013-05, Vol.8 (5), p.e63691-e63691
Main Authors: Wen, Xuyun, Wu, Xia, Liu, Jiangtao, Li, Ke, Yao, Li
Format: Article
Language:English
Subjects:
Biology
Brain
Brain - physiopathology
Brain mapping
Brain research
Depression (Mood disorder)
Depression - etiology
Depression - physiopathology
Depressive Disorder, Major - physiopathology
Family medical history
Female
Functional magnetic resonance imaging
Health aspects
Hospitals
Humans
Information science
Laboratories
Magnetic resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medical research
Medicine
Mental depression
Middle Aged
Movement disorders
Neurodegenerative diseases
Neuroimaging
Neurosciences
NMR
Nuclear magnetic resonance
Parkinson Disease - complications
Parkinson Disease - physiopathology
Parkinson's disease
Patients
Prefrontal cortex
Prefrontal Cortex - physiopathology
Resonance
Scanners
Studies
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Summary:Depression is the most common psychiatric disorder observed in Parkinson's disease (PD) patients, however the neural contribution to the high rate of depression in the PD group is still unclear. In this study, we used resting-state functional magnetic resonance imaging (fMRI) to investigate the underlying neural mechanisms of depression in PD patients. Twenty-one healthy individuals and thirty-three patients with idiopathic PD, seventeen of whom were diagnosed with major depressive disorder, were recruited. An analysis of amplitude of low-frequency fluctuations (ALFF) was performed on the whole brain of all subjects. Our results showed that depressed PD patients had significantly decreased ALFF in the dorsolateral prefrontal cortex (DLPFC), the ventromedial prefrontal cortex (vMPFC) and the rostral anterior cingulated cortex (rACC) compared with non-depressed PD patients. A significant positive correlation was found between Hamilton Depression Rating Scale (HDRS) and ALFF in the DLPFC. The findings of changed ALFF in these brain regions implied depression in PD patients may be associated with abnormal activities of prefrontal-limbic network.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0063691