The clinical characteristics, carbapenem resistance, and outcome of Acinetobacter bacteremia according to genospecies

Few clinical data are available on the relationship between genospecies and outcome of Acinetobacter bacteremia, and the results are inconsistent. We performed this study to evaluate the relationship between genospecies and the outcome of Acinetobacter bacteremia. Clinical data from 180 patients who...

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Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e65026-e65026
Main Authors: Park, Kyung-Hwa, Shin, Jong-Hee, Lee, Seung Yeop, Kim, Soo Hyun, Jang, Mi Ok, Kang, Seung-Ji, Jung, Sook-In, Chung, Eun-Kyung, Ko, Kwan Soo, Jang, Hee-Chang
Format: Article
Language:English
Subjects:
Acinetobacter
Acinetobacter - drug effects
Acinetobacter - genetics
Acinetobacter baumannii
Acinetobacter Infections - drug therapy
Acinetobacter Infections - microbiology
Acinetobacter Infections - mortality
Adult
Antibiotics
Antimicrobial agents
Automation
Bacteremia
Bacteremia - drug therapy
Bacteremia - microbiology
Bacteremia - mortality
Biology
Carbapenems - pharmacology
Carbapenems - therapeutic use
Causes of
Complications and side effects
Development and progression
Drug resistance
Drug Resistance, Bacterial - drug effects
Drug therapy
Empirical analysis
Female
Genotype
Genotype & phenotype
Hospitals
Humans
Infectious diseases
Kaplan-Meier Estimate
Laboratories
Male
Mechanical ventilation
Medical schools
Medicine
Microbial drug resistance
Middle Aged
Mortality
Multidrug resistance
Multivariate analysis
Patient outcomes
Patients
Physiological aspects
Pneumonia
Risk analysis
Risk Factors
RpoB protein
Staphylococcus infections
Treatment Outcome
Ventilation
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Summary:Few clinical data are available on the relationship between genospecies and outcome of Acinetobacter bacteremia, and the results are inconsistent. We performed this study to evaluate the relationship between genospecies and the outcome of Acinetobacter bacteremia. Clinical data from 180 patients who had Acinetobacter bacteremia from 2003 to 2010 were reviewed retrospectively. The genospecies were identified by rpoB gene sequence analysis. The clinical features and outcomes of 90 patients with A. baumannii bacteremia were compared to those of 90 patients with non-baumannii Acinetobacter bacteremia (60 with A. nosocomialis, 17 with Acinetobacter species "close to 13 TU", 11 with A. pittii, and two with A. calcoaceticus). A. baumannii bacteremia was associated with intensive care unit-onset, mechanical ventilation, pneumonia, carbapenem resistance, and higher APACHE II scores, compared to non-baumannii Acinetobacter bacteremia (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0065026