Mild obesity, physical activity, calorie intake, and the risks of cervical intraepithelial neoplasia and cervical cancer

We investigated whether obesity, physical activity, and calorie intake are associated with the risks of cervical intraepithelial neoplasia (CIN) and cervical cancer. We enrolled 1125 women (age, 18-65 years) into a human papillomavirus cohort study established from 2006 to 2012. Multinomial logistic...

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Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e66555-e66555
Main Authors: Lee, Jae Kwan, So, Kyeong A, Piyathilake, Chandrika J, Kim, Mi Kyung
Format: Article
Language:English
Subjects:
Adult
Alcohol use
Body mass
Body Mass Index
Body size
Body weight
Cancer
Cervical cancer
Cervical Intraepithelial Neoplasia - epidemiology
Cervical Intraepithelial Neoplasia - etiology
Cervical Intraepithelial Neoplasia - prevention & control
Cervix
Cervix dysplasia
Confidence intervals
Development and progression
Endometrial cancer
Energy Intake - physiology
Exercise
Female
Health aspects
Health risk assessment
Health risks
Human papillomavirus
Humans
Logistic Models
Medicine
Middle Aged
Motor Activity - physiology
Obesity
Obesity - complications
Odds Ratio
Overweight
Papillomavirus infections
Physical activity
Regression analysis
Regression models
Risk Factors
Statistical analysis
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - etiology
Uterine Cervical Neoplasms - prevention & control
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Summary:We investigated whether obesity, physical activity, and calorie intake are associated with the risks of cervical intraepithelial neoplasia (CIN) and cervical cancer. We enrolled 1125 women (age, 18-65 years) into a human papillomavirus cohort study established from 2006 to 2012. Multinomial logistic regression models were used to estimate crude and multivariate odds ratios (ORs) and the corresponding 95% confidence intervals (95% CIs), and to assess whether body mass index (BMI), height, weight, total calorie intake, and physical activity were associated with the risks of CIN and cervical cancer. Cervical cancer risk was positively associated with BMI and inversely associated with physical activity. When compared with women with a normal BMI (18.5-23 kg/m(2)), the multivariate ORs (95% CIs) for those overweight (23-25 kg/m(2)) and mild obesity (≥25 kg/m(2)) were 1.25 (0.79-2.00) and 1.70 (1.10-2.63), respectively. When compared with women with the lowest tertile of physical activity (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0066555