Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway

• Published in: PloS one 2013-06, Vol.8 (6), p.e63676-e63676
• Main Authors: Tang, Zhong-Ping, Dong, Qian-Ze, Cui, Quan-Zhe, Papavassiliou, Paulie, Wang, En-Di, Wang, En-Hua
• Format: Article
• Language: English
• Subjects: Apoptosis; Ataxia; Ataxia telangiectasia; Biology; Blotting, Western; Breast cancer; c-Myc protein; Cancer; Cancer therapies; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - physiopathology; Cell cycle; Cell Cycle - physiology; Cell growth; Cell Line, Tumor; Cell Proliferation; Chemotherapy; China; Cyclin D1; Cyclin D1 - metabolism; Depletion; DNA Primers - genetics; DNA-Binding Proteins - metabolism; Epithelial cells; G1 phase; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic - physiology; Hospitals; Humans; Immunohistochemistry; Kinases; Luciferases; Lung cancer; Lung diseases; Lymphatic system; Medical prognosis; Medicine; Metastasis; Myc protein; NF-kappa B - metabolism; NF-κB protein; Non-small cell lung carcinoma; p53 Protein; Pathology; Proteins; Proto-Oncogene Proteins c-myc - metabolism; Real-Time Polymerase Chain Reaction; RNA, Small Interfering - genetics; S phase; Signal transduction; Signal Transduction - physiology; Signaling; siRNA; Stomach cancer; Studies; Transcription Factors - metabolism; Tumor Stem Cell Assay; Tumors; Wnt protein; β-Catenin
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0063676

Previous studies suggested Ataxia-telangiectasia group D complementing gene (ATDC) as an oncogene in many types of cancer. However, its expression and biological functions in non-small cell lung cancer (NSCLC) remain unclear. Herein, we investigated its expression pattern in 109 cases of human NSCLC samples by immunohistochemistry and found that ATDC was overexpressed in 62 of 109 NSCLC samples (56.88%). ATDC overexpression correlated with histological type (p