Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice

Monocarboxylate transporter 8 (MCT8) is a well-established thyroid hormone (TH) transporter. In humans, MCT8 mutations result in changes in circulating TH concentrations and X-linked severe global neurodevelopmental delay. MCT8 is expressed in the human placenta throughout gestation, with increased...

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Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e65402-e65402
Main Authors: Vasilopoulou, Elisavet, Loubière, Laurence S, Heuer, Heike, Trajkovic-Arsic, Marija, Darras, Veerle M, Visser, Theo J, Lash, Gendie E, Whitley, Guy S, McCabe, Christopher J, Franklyn, Jayne A, Kilby, Mark D, Chan, Shiao Y
Format: Article
Language:English
Subjects:
Age
Analysis
Analysis of Variance
Animals
Apoptosis - physiology
Biology
Cell Movement - physiology
Cell Proliferation
Cells, Cultured
Concentration (composition)
Endocrinology
England
Female
Fetuses
Genes
Gestation
Humans
Insulin-like growth factors
Medicine
Membrane Transport Proteins - genetics
Mice
Mice, Knockout
Monocarboxylic Acid Transporters - metabolism
Morphology
Mutation
Organ Size
Overexpression
Placenta
Placenta - cytology
Placenta - metabolism
Placentation
Pregnancy
Proteins
R&D
Research & development
RNA, Small Interfering - genetics
Studies
Thorium
Thyroid
Thyroid gland
Thyroid Hormones - metabolism
Triiodothyronine
Trophoblasts - metabolism
Weight reduction
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Summary:Monocarboxylate transporter 8 (MCT8) is a well-established thyroid hormone (TH) transporter. In humans, MCT8 mutations result in changes in circulating TH concentrations and X-linked severe global neurodevelopmental delay. MCT8 is expressed in the human placenta throughout gestation, with increased expression in trophoblast cells from growth-restricted pregnancies. We postulate that MCT8 plays an important role in placental development and transplacental TH transport. We investigated the effect of altering MCT8 expression in human trophoblast in vitro and in a Mct8 knockout mouse model. Silencing of endogenous MCT8 reduced T3 uptake into human extravillous trophoblast-like cells (SGHPL-4; 40%, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0065402