Hypomethylation of serum blood clot DNA, but not plasma EDTA-blood cell pellet DNA, from vitamin B12-deficient subjects

Vitamin B12, a co-factor in methyl-group transfer, is important in maintaining DNA (deoxycytidine) methylation. Using two independent assays we examined the effect of vitamin B12-deficiency (plasma vitamin B12

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Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e65241-e65241
Main Authors: Quinlivan, Eoin P, Crider, Krista S, Zhu, Jiang-Hui, Maneval, David R, Hao, Ling, Li, Zhu, Rasmussen, Sonja A, Berry, R J, Bailey, Lynn B
Format: Article
Language:English
Subjects:
Adult
Biochemistry
Biological activity
Biology
Birth defects
Blood
Blood cells
Blood coagulation
Carbon
Cell cycle
Cloning
Collection
Consent
Cyanocobalamin
Deoxycytidine - metabolism
Deoxyribonucleic acid
Developmental disabilities
Disease control
Disease prevention
DNA
DNA - blood
DNA Methylation
Edetic acid
Epigenetic inheritance
Epigenetics
Ethylenediaminetetraacetic acids
Female
Folic Acid - blood
Gene expression
Genetic research
Humans
Medicine
Methylation
Nutrition research
Risk assessment
Sampling methods
Science
Vitamin B
Vitamin B 12 - blood
Vitamin B 12 Deficiency - blood
Vitamin B 12 Deficiency - genetics
Vitamin B12
Vitamin deficiency
Vitamins
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Description
Summary:Vitamin B12, a co-factor in methyl-group transfer, is important in maintaining DNA (deoxycytidine) methylation. Using two independent assays we examined the effect of vitamin B12-deficiency (plasma vitamin B12
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0065241