Side effects: substantial non-neutral evolution flanking regulatory sites

  In the pre-genome era, most of what we knew about molecular evolution could be traced to our knowledge of the genetic code, and the impact of DNA sequence variation on protein structure and, by inference, protein function [1]. The specific regions of the human genome known to be bound by transcrip...

Full description

Saved in:
Bibliographic Details
Published in:PLoS genetics 2013-05, Vol.9 (5), p.e1003528-e1003528
Main Authors: Prendergast, James G D, Semple, Colin A
Format: Article
Language:English
Subjects:
Animals
Biology
Chromatin - genetics
Conserved Sequence - genetics
Deoxyribonucleic acid
DNA
Drosophila melanogaster - genetics
Genetic Drift
Genetic regulation
Genetics
Genomes
Genomics
Insects
Nucleosomes - genetics
Protein-protein interactions
Proteins
RNA, Untranslated - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:  In the pre-genome era, most of what we knew about molecular evolution could be traced to our knowledge of the genetic code, and the impact of DNA sequence variation on protein structure and, by inference, protein function [1]. The specific regions of the human genome known to be bound by transcription factors often display remarkable patterns of conservation that parallel the structure of the DNA-binding interface of the protein involved [4].
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1003528