The open access malaria box: a drug discovery catalyst for neglected diseases

Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite, Plasmodium falciparum has yielded almost 30,000 submicromolar hits in recent years. To make this collection more accessible, a...

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Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e62906-e62906
Main Authors: Spangenberg, Thomas, Burrows, Jeremy N, Kowalczyk, Paul, McDonald, Simon, Wells, Timothy N C, Willis, Paul
Format: Article
Language:English
Subjects:
Analysis
Antimalarials - pharmacology
Antimalarials - therapeutic use
Biological products
Biology
Chemistry
Children & youth
Collection
Datasets
Design
Disease
Drug Discovery
Drug Evaluation, Preclinical
Drug therapy
Historical account
Humans
Library collections
Malaria
Malaria, Falciparum - drug therapy
Medicine
Open access
Parasites
Pathogens
Pharmaceutical sciences
Pharmacology
Plasmodium
Plasmodium falciparum
R&D
Research & development
Tropical diseases
Vector-borne diseases
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Summary:Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite, Plasmodium falciparum has yielded almost 30,000 submicromolar hits in recent years. To make this collection more accessible, a collection of 400 chemotypes has been assembled, termed the Malaria Box. Half of these compounds were selected based on their drug-like properties and the others as molecular probes. These can now be requested as a pharmacological test set by malaria biologists, but importantly by groups working on related parasites, as part of a program to make both data and compounds readily available. In this paper, the analysis and selection methodology and characteristics of the compounds are described.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0062906