Legume consumption and colorectal adenoma risk: a meta-analysis of observational studies

The anticancer effects of legumes have been explored extensively, but evidence from epidemiologic studies on colorectal adenoma is controversial. We performed a meta-analysis to assess these issues. A systemic search of several databases was conducted for relevant studies evaluating the relationship...

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Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e67335-e67335
Main Authors: Wang, Yunqian, Wang, Zhenhua, Fu, Linna, Chen, Yingxuan, Fang, Jingyuan
Format: Article
Language:English
Subjects:
Adenoma
Adenoma - pathology
Anticancer properties
Bibliographic data bases
Biomarkers
Cell growth
Cohort analysis
Colorectal cancer
Colorectal Neoplasms - pathology
Confidence Intervals
Diet
Disease prevention
Epidemiology
Fabaceae - metabolism
Feeding Behavior
Food
Gastroenterology
Health risk assessment
Hepatology
Hospitals
Humans
Laboratories
Legumes
Medical ethics
Medical research
Medicine
Meta-analysis
Nutrition research
Observational studies
Observational Studies as Topic
Publication Bias
Risk analysis
Risk Factors
Soybeans
Studies
Tumors
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Summary:The anticancer effects of legumes have been explored extensively, but evidence from epidemiologic studies on colorectal adenoma is controversial. We performed a meta-analysis to assess these issues. A systemic search of several databases was conducted for relevant studies evaluating the relationship between legume intake and adenoma risk, with no language restriction, from January 1, 1966, to April 1, 2013. Three cohort and eleven case control studies with 8,380 cases and a total of 101,856 participants were included in the analysis; the pooled odds ratio (95% confidence interval) for the highest vs. lowest consumption categories was 0.83 (0.75-0.93), with moderate level of heterogeneity (I(2) = 25.9% and P = 0.146) based on a random effects model. A decreased risk of adenoma was also observed in most of our subgroup meta-analyses. Higher intake of legumes significantly reduced the risk of colorectal adenoma in our meta-analysis. Nevertheless, due to possible confounders and bias, further investigations are warranted to confirm this relationship.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0067335