Inter subject variability and reproducibility of diffusion tensor imaging within and between different imaging sessions

The aim of these studies was to provide reference data on intersubject variability and reproducibility of diffusion tensor imaging. Healthy volunteers underwent imaging on two occasions using the same 3T Siemens Verio magnetic resonance scanner. At each session two identical diffusion tensor sequenc...

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Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e65941-e65941
Main Authors: Veenith, Tonny V, Carter, Eleanor, Grossac, Julia, Newcombe, Virginia F J, Outtrim, Joanne G, Lupson, Victoria, Williams, Guy B, Menon, David K, Coles, Jonathan P
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Anisotropy
Automation
Biology
Brain
Brain injury
Coefficient of variation
Correlation analysis
Diffusion
Diffusion coefficient
Diffusion Tensor Imaging - methods
Diffusion Tensor Imaging - standards
Diffusivity
Female
Head injuries
Humans
Imaging
Longitudinal studies
Magnetic resonance
Magnetic resonance imaging
Male
Mathematical analysis
Medical imaging
Medicine
Neuroimaging
Neuroimaging - methods
Neuroimaging - standards
Quality Improvement
Reference Values
Reproducibility
Reproducibility of Results
Scanners
Social and Behavioral Sciences
Studies
Traumatic brain injury
Variability
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Summary:The aim of these studies was to provide reference data on intersubject variability and reproducibility of diffusion tensor imaging. Healthy volunteers underwent imaging on two occasions using the same 3T Siemens Verio magnetic resonance scanner. At each session two identical diffusion tensor sequences were obtained along with standard structural imaging. Fractional anisotropy, apparent diffusion coefficient, axial and radial diffusivity maps were created and regions of interest applied in normalised space. The baseline data from all 26 volunteers were used to calculate the intersubject variability, while within session and between session reproducibility were calculated from all the available data. The reproducibility of measurements were used to calculate the overall and within session 95% prediction interval for zero change. The within and between session reproducibility data were lower than the values for intersubject variability, and were different across the brain. The regional mean (range) coefficient of variation figures for within session reproducibility were 2.1 (0.9-5.5%), 1.2 (0.4-3.9%), 1.2 (0.4-3.8%) and 1.8 (0.4-4.3%) for fractional anisotropy, apparent diffusion coefficient, axial and radial diffusivity, and were lower than between session reproducibility measurements (2.4 (1.1-5.9%), 1.9 (0.7-5.7%), 1.7 (0.7-4.7%) and 2.4 (0.9-5.8%); p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0065941