Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival

Recurrence and progression to higher grade lesions are characteristic behaviors of gliomas. Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of gliomas. We therefore analysed IDH1 and IDH2 st...

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Published in:PloS one 2013-06, Vol.8 (6), p.e67421-e67421
Main Authors: Yao, Yu, Chan, Aden Ka-Yin, Qin, Zhi Yong, Chen, Ling Chao, Zhang, Xin, Pang, Jesse Chung-Sean, Li, Hiu Ming, Wang, Yin, Mao, Ying, Ng, Ho-Keung, Zhou, Liang Fu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antigens
Astrocytoma - genetics
Astrocytoma - mortality
Astrocytoma - pathology
Biology
Brain cancer
Brain Neoplasms - genetics
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Brain tumors
Child
Child, Preschool
Disease Progression
Disease-Free Survival
DNA Mutational Analysis
Ethics
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genomes
Glioma
Humans
Immunohistochemistry
Isocitrate Dehydrogenase - genetics
Kaplan-Meier Estimate
Lesions
Male
Medical prognosis
Medicine
Middle Aged
Multivariate Analysis
Mutation
Mutation, Missense
Neoplasm Recurrence, Local - genetics
Nervous system
Neurosurgery
Pathology
Patients
Prognosis
Proportional Hazards Models
Statistical analysis
Survival
Tumors
Young Adult
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cited_by cdi_FETCH-LOGICAL-c526t-15e57fb6beacbb80cc7a91381982f495bca968c3a650ffaf5eac01174937631a3
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container_issue 6
container_start_page e67421
container_title PloS one
container_volume 8
creator Yao, Yu
Chan, Aden Ka-Yin
Qin, Zhi Yong
Chen, Ling Chao
Zhang, Xin
Pang, Jesse Chung-Sean
Li, Hiu Ming
Wang, Yin
Mao, Ying
Ng, Ho-Keung
Zhou, Liang Fu
description Recurrence and progression to higher grade lesions are characteristic behaviors of gliomas. Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of gliomas. We therefore analysed IDH1 and IDH2 status at codon 132 of IDH1 and codon 172 of IDH2 by direct sequencing and anti-IDH1-R132H immunohistochemistry in 53 paired samples and their recurrences, including 29 low-grade gliomas, 16 anaplastic gliomas and 8 Glioblastomas. IDH1/IDH2 mutation was detected in 32 primary tumors, with 25 low-grade gliomas and 6 anaplastic gliomas harboring IDH1 mutation and 1 low-grade glioma harboring IDH2 mutation. All of the paired tumors showed consistent IDH1 and IDH2 status. Patients were analyzed according to IDH1 status and tumor-related factors. Malignant progression at recurrence was noted in 22 gliomas and was not associated with IDH1 mutation. Survival analysis revealed patients with IDH1 mutated gliomas had a significantly longer progression-free survival (PFS) and overall survival (OS). In conclusion, this study demonstrated a strong tendency of IDH1/IDH2 status being consistent during progression of glioma. IDH1 mutation was not a predictive marker for malignant progression and it was a potential prognostic marker for gliomas of Chinese patients.
doi_str_mv 10.1371/journal.pone.0067421
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Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of gliomas. We therefore analysed IDH1 and IDH2 status at codon 132 of IDH1 and codon 172 of IDH2 by direct sequencing and anti-IDH1-R132H immunohistochemistry in 53 paired samples and their recurrences, including 29 low-grade gliomas, 16 anaplastic gliomas and 8 Glioblastomas. IDH1/IDH2 mutation was detected in 32 primary tumors, with 25 low-grade gliomas and 6 anaplastic gliomas harboring IDH1 mutation and 1 low-grade glioma harboring IDH2 mutation. All of the paired tumors showed consistent IDH1 and IDH2 status. Patients were analyzed according to IDH1 status and tumor-related factors. Malignant progression at recurrence was noted in 22 gliomas and was not associated with IDH1 mutation. Survival analysis revealed patients with IDH1 mutated gliomas had a significantly longer progression-free survival (PFS) and overall survival (OS). In conclusion, this study demonstrated a strong tendency of IDH1/IDH2 status being consistent during progression of glioma. 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Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of gliomas. We therefore analysed IDH1 and IDH2 status at codon 132 of IDH1 and codon 172 of IDH2 by direct sequencing and anti-IDH1-R132H immunohistochemistry in 53 paired samples and their recurrences, including 29 low-grade gliomas, 16 anaplastic gliomas and 8 Glioblastomas. IDH1/IDH2 mutation was detected in 32 primary tumors, with 25 low-grade gliomas and 6 anaplastic gliomas harboring IDH1 mutation and 1 low-grade glioma harboring IDH2 mutation. All of the paired tumors showed consistent IDH1 and IDH2 status. Patients were analyzed according to IDH1 status and tumor-related factors. Malignant progression at recurrence was noted in 22 gliomas and was not associated with IDH1 mutation. Survival analysis revealed patients with IDH1 mutated gliomas had a significantly longer progression-free survival (PFS) and overall survival (OS). In conclusion, this study demonstrated a strong tendency of IDH1/IDH2 status being consistent during progression of glioma. IDH1 mutation was not a predictive marker for malignant progression and it was a potential prognostic marker for gliomas of Chinese patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23840696</pmid><doi>10.1371/journal.pone.0067421</doi><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Aged
Antigens
Astrocytoma - genetics
Astrocytoma - mortality
Astrocytoma - pathology
Biology
Brain cancer
Brain Neoplasms - genetics
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Brain tumors
Child
Child, Preschool
Disease Progression
Disease-Free Survival
DNA Mutational Analysis
Ethics
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genomes
Glioma
Humans
Immunohistochemistry
Isocitrate Dehydrogenase - genetics
Kaplan-Meier Estimate
Lesions
Male
Medical prognosis
Medicine
Middle Aged
Multivariate Analysis
Mutation
Mutation, Missense
Neoplasm Recurrence, Local - genetics
Nervous system
Neurosurgery
Pathology
Patients
Prognosis
Proportional Hazards Models
Statistical analysis
Survival
Tumors
Young Adult
title Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival
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