Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α

Solid tumors are characterized by regions of low oxygen tension (OT), which play a central role in tumor progression and resistance to therapy. Low OT affects mitochondrial function and for the cells to survive, mitochondria must functionally adapt to low OT to maintain the cellular bioenergetics. I...

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Bibliographic Details
Published in:PloS one 2013-06, Vol.8 (6), p.e68348-e68348
Main Authors: Diers, Anne R, Vayalil, Praveen K, Oliva, Claudia R, Griguer, Corinne E, Darley-Usmar, Victor, Hurst, Douglas R, Welch, Danny R, Landar, Aimee
Format: Article
Language:English
Subjects:
Acidification
Adaptation
Adaptation, Biological - genetics
Adaptation, Biological - physiology
Bioenergetics
Biology
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - physiopathology
Cancer
Cardiomyocytes
Cell Line, Tumor
Cell Respiration - genetics
Cell Respiration - physiology
Chemical compounds
Electron transport
Energy Metabolism - genetics
Energy Metabolism - physiology
Female
Free radicals
Gene expression
Glucose - metabolism
Glycolysis - genetics
Glycolysis - physiology
Humans
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit - genetics
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Kinases
Medicine
Metabolism
Metastases
Metastasis
Mitochondria
Mitochondria - genetics
Mitochondria - metabolism
Mitochondria - pathology
Mitochondria - physiology
Neoplasm Metastasis - genetics
Neoplasm Metastasis - physiopathology
Oxygen
Oxygen - metabolism
Oxygen consumption
Oxygen Consumption - genetics
Oxygen Consumption - physiology
Oxygen tension
Pathology
Pharmacology
Respiration
Rodents
Solid tumors
Tension
Tumors
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Summary:Solid tumors are characterized by regions of low oxygen tension (OT), which play a central role in tumor progression and resistance to therapy. Low OT affects mitochondrial function and for the cells to survive, mitochondria must functionally adapt to low OT to maintain the cellular bioenergetics. In this study, a novel experimental approach was developed to examine the real-time bioenergetic changes in breast cancer cells (BCCs) during adaptation to OT (from 20% to
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0068348