Tumor selective hyperthermia induced by short-wave capacitively-coupled RF electric-fields

There is a renewed interest in developing high-intensity short wave capacitively-coupled radiofrequency (RF) electric-fields for nanoparticle-mediated tumor-targeted hyperthermia. However, the direct thermal effects of such high-intensity electric-fields (13.56 MHZ, 600 W) on normal and tumor tissue...

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Bibliographic Details
Published in:PloS one 2013-07, Vol.8 (7), p.e68506
Main Authors: Raoof, Mustafa, Cisneros, Brandon T, Corr, Stuart J, Palalon, Flavio, Curley, Steven A, Koshkina, Nadezhda V
Format: Article
Language:English
Subjects:
Analysis
Animal tissues
Animals
Anticancer properties
Cancer
Cancer therapies
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Care and treatment
Cell Line, Tumor
Chemistry
Dielectric properties
Electric fields
Electrical properties
Electricity
Electromagnetic Fields
Electromagnetic Radiation
Engineering
Female
Fever
Human behavior
Humans
Hyperthermia
Hyperthermia treatment equipment
Hyperthermia, Induced - instrumentation
Hyperthermia, Induced - methods
Laboratory animals
Liver cancer
Liver Neoplasms, Experimental - pathology
Liver Neoplasms, Experimental - therapy
Medicine
Mice
Mice, SCID
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Oncology
Organ Specificity
Pancreatic cancer
Pancreatic carcinoma
Pancreatic Neoplasms
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - therapy
Physics
Radio frequency
Rodents
Studies
Temperature effects
Transplantation, Heterologous
Tumors
Xenografts
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Summary:There is a renewed interest in developing high-intensity short wave capacitively-coupled radiofrequency (RF) electric-fields for nanoparticle-mediated tumor-targeted hyperthermia. However, the direct thermal effects of such high-intensity electric-fields (13.56 MHZ, 600 W) on normal and tumor tissues are not completely understood. In this study, we investigate the heating behavior and dielectric properties of normal mouse tissues and orthotopically-implanted human hepatocellular and pancreatic carcinoma xenografts. We note tumor-selective hyperthermia (relative to normal mouse tissues) in implanted xenografts that can be explained on the basis of differential dielectric properties. Furthermore, we demonstrate that repeated RF exposure of tumor-bearing mice can result in significant anti-tumor effects compared to control groups without detectable harm to normal mouse tissues.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0068506