Sex-specific effects on spatial learning and memory, and sex-independent effects on blood pressure of a <3.3 Mbp rat chromosome 2 QTL region in Dahl salt-sensitive rats

Epidemiological studies have consistently found that hypertension is associated with poor cognitive performance. We hypothesize that a putative causal mechanism underlying this association is due to genetic loci affecting both blood pressure and cognition. Consistent with this notion, we reported se...

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Bibliographic Details
Published in:PloS one 2013-07, Vol.8 (7), p.e67673-e67673
Main Authors: Herrera, Victoria L, Pasion, Khristine A, Tan, Glaiza A, Moran, Ann Marie, Ruiz-Opazo, Nelson
Format: Article
Language:English
Subjects:
Analysis
Animals
Animals, Congenic
Biology
Blood
Blood Pressure
Blood Pressure Determination
Care and treatment
Chromosome 2
Chromosome Mapping
Chromosomes
Chromosomes, Mammalian
Cognition
Cognitive ability
Cognitive tasks
Epidemiology
Female
Females
Gene mapping
Genomics
Hypertension
Hypertension - genetics
Hypertension - physiopathology
Hypertension - psychology
Male
Males
Maze Learning
Medicine
Memory
Navigation
Navigation behavior
Pressure effects
Quantitative Trait Loci
Rats
Rats, Inbred Dahl
Risk factors
Rodents
Salts
Sex
Sex Factors
Space Perception
Spatial discrimination learning
Spatial memory
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Summary:Epidemiological studies have consistently found that hypertension is associated with poor cognitive performance. We hypothesize that a putative causal mechanism underlying this association is due to genetic loci affecting both blood pressure and cognition. Consistent with this notion, we reported several blood pressure (BP) quantitative trait loci (QTLs) that co-localized with navigational performance (Nav)-QTLs influencing spatial learning and memory in Dahl rats. The present study investigates a chromosome 2 region harboring BP-f4 and Nav-8 QTLs. We developed two congenic strains, S.R2A and S.R2B introgressing Dahl R-chromosome 2 segments into Dahl S chromosome 2 region spanning BP-f4 and Nav-8 QTLs. Radiotelemetric blood pressure analysis identified only S.R2A congenic rats with lower systolic blood pressure (females: -26.0 mmHg, P = 0.003; males: -30.9 mmHg, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0067673