Towards an elastographic atlas of brain anatomy

Cerebral viscoelastic constants can be measured in a noninvasive, image-based way by magnetic resonance elastography (MRE) for the detection of neurological disorders. However, MRE brain maps of viscoelastic constants are still limited by low spatial resolution. Here we introduce three-dimensional m...

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Published in:PloS one 2013-08, Vol.8 (8), p.e71807-e71807
Main Authors: Guo, Jing, Hirsch, Sebastian, Fehlner, Andreas, Papazoglou, Sebastian, Scheel, Michael, Braun, Juergen, Sack, Ingolf
Format: Article
Language:English
Subjects:
Adult
Aged
Alzheimer's disease
Alzheimers disease
Anatomy
Biology
Brain
Brain - physiology
Brain mapping
Brain Mapping - methods
Caudate nucleus
Corpus callosum
Elasticity Imaging Techniques - methods
Female
Fractals
Head
Healthy Volunteers
Humans
Image detection
Magnetic resonance
Magnetic Resonance Imaging
Male
Mathematics
Medicine
Middle Aged
Multiple sclerosis
Nervous system diseases
Neurological diseases
NMR
Nuclear magnetic resonance
Oscillations
Shear modulus
Spatial discrimination
Spatial resolution
Stiffness
Substantia alba
Thalamus
Therapeutic applications
Viscoelasticity
Young Adult
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cited_by cdi_FETCH-LOGICAL-c692t-5820c3d16db7c578368d144d42e53ac2fab7192f8f00d9ec2d8c89e4c60643c43
cites cdi_FETCH-LOGICAL-c692t-5820c3d16db7c578368d144d42e53ac2fab7192f8f00d9ec2d8c89e4c60643c43
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container_issue 8
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container_title PloS one
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creator Guo, Jing
Hirsch, Sebastian
Fehlner, Andreas
Papazoglou, Sebastian
Scheel, Michael
Braun, Juergen
Sack, Ingolf
description Cerebral viscoelastic constants can be measured in a noninvasive, image-based way by magnetic resonance elastography (MRE) for the detection of neurological disorders. However, MRE brain maps of viscoelastic constants are still limited by low spatial resolution. Here we introduce three-dimensional multifrequency MRE of the brain combined with a novel reconstruction algorithm based on a model-free multifrequency inversion for calculating spatially resolved viscoelastic parameter maps of the human brain corresponding to the dynamic range of shear oscillations between 30 and 60 Hz. Maps of two viscoelastic parameters, the magnitude and the phase angle of the complex shear modulus, |G*| and φ, were obtained and normalized to group templates of 23 healthy volunteers in the age range of 22 to 72 years. This atlas of the anatomy of brain mechanics reveals a significant contrast in the stiffness parameter |G*| between different anatomical regions such as white matter (WM; 1.252±0.260 kPa), the corpus callosum genu (CCG; 1.104±0.280 kPa), the thalamus (TH; 1.058±0.208 kPa) and the head of the caudate nucleus (HCN; 0.649±0.101 kPa). φ, which is sensitive to the lossy behavior of the tissue, was in the order of CCG (1.011±0.172), TH (1.037±0.173), CN (0.906±0.257) and WM (0.854±0.169). The proposed method provides the first normalized maps of brain viscoelasticity with anatomical details in subcortical regions and provides useful background data for clinical applications of cerebral MRE.
doi_str_mv 10.1371/journal.pone.0071807
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1932-6203
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source Publicly Available Content Database; PubMed Central
subjects Adult
Aged
Alzheimer's disease
Alzheimers disease
Anatomy
Biology
Brain
Brain - physiology
Brain mapping
Brain Mapping - methods
Caudate nucleus
Corpus callosum
Elasticity Imaging Techniques - methods
Female
Fractals
Head
Healthy Volunteers
Humans
Image detection
Magnetic resonance
Magnetic Resonance Imaging
Male
Mathematics
Medicine
Middle Aged
Multiple sclerosis
Nervous system diseases
Neurological diseases
NMR
Nuclear magnetic resonance
Oscillations
Shear modulus
Spatial discrimination
Spatial resolution
Stiffness
Substantia alba
Thalamus
Therapeutic applications
Viscoelasticity
Young Adult
title Towards an elastographic atlas of brain anatomy
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