Intratumoral α-SMA enhances the prognostic potency of CD34 associated with maintenance of microvessel integrity in hepatocellular carcinoma and pancreatic cancer

Microvessel density (MVD) as an angiogenesis predictor is inefficient per se in cancer prognosis. We evaluated prognostic values of combining intratumoral alpha-smooth muscle actin (α-SMA)-positive stromal cell density and MVD after curative resection in hypervascular hepatocellular carcinoma (HCC)...

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Published in:PloS one 2013-08, Vol.8 (8), p.e71189-e71189
Main Authors: Wang, Wen-Quan, Liu, Liang, Xu, Hua-Xiang, Luo, Guo-Pei, Chen, Tao, Wu, Chun-Tao, Xu, Yong-Feng, Xu, Jin, Liu, Chen, Zhang, Bo, Long, Jiang, Tang, Zhao-You, Yu, Xian-Jun
Format: Article
Language:English
Subjects:
Actin
Actins - metabolism
Angiogenesis
Antigens, CD34 - metabolism
Biomarkers, Tumor - metabolism
Cancer
Carcinoma, Hepatocellular - blood supply
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
CD34 antigen
Cell Count
Cell density
Cell survival
Cohort Studies
Density
Diplomatic recognition
Endothelial cells
Hepatocellular carcinoma
Humans
Integrity
Kinases
Liver cancer
Liver Neoplasms - blood supply
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Lymph nodes
MBA programs & graduates
Medical prognosis
Medicine
Metastases
Microvasculature
Microvessels - pathology
Muscles
Pancreatic cancer
Pancreatic carcinoma
Pancreatic Neoplasms - blood supply
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Patients
Predictive Value of Tests
Prognosis
Proteins
Silk
Smooth muscle
Survival
Survival Analysis
Tissue Array Analysis
Tumors
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Summary:Microvessel density (MVD) as an angiogenesis predictor is inefficient per se in cancer prognosis. We evaluated prognostic values of combining intratumoral alpha-smooth muscle actin (α-SMA)-positive stromal cell density and MVD after curative resection in hypervascular hepatocellular carcinoma (HCC) and hypovascular pancreatic cancer (PC). Tissue microarrays were constructed from tumors of 305 HCC and 57 PC patients who underwent curative resection and analyzed for α-SMA and CD34 expression by immunostaining. Prognostic values of these two proteins and other clinicopathological features were examined. Both low α-SMA density and high MVD-CD34 were associated in HCC with the presence of intrahepatic metastasis and microvascular invasion, and they were related to lymph node involvement and microvascular invasion in PC (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0071189