Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

• Published in: PLoS genetics 2013-06, Vol.9 (6), p.e1003500-e1003500
• Main Authors: Randall, Joshua C, Winkler, Thomas W, Kutalik, Zoltán, Berndt, Sonja I, Jackson, Anne U, Monda, Keri L, Kilpeläinen, Tuomas O, Esko, Tõnu, Mägi, Reedik, Li, Shengxu, Workalemahu, Tsegaselassie, Feitosa, Mary F, Croteau-Chonka, Damien C, Day, Felix R, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Locke, Adam E, Mathieson, Iain, Scherag, Andre, Vedantam, Sailaja, Wood, Andrew R, Liang, Liming, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Dermitzakis, Emmanouil T, Dimas, Antigone S, Karpe, Fredrik, Min, Josine L, Nicholson, George, Clegg, Deborah J, Person, Thomas, Krohn, Jon P, Bauer, Sabrina, Buechler, Christa, Eisinger, Kristina, Bonnefond, Amélie, Froguel, Philippe, Hottenga, Jouke-Jan, Prokopenko, Inga, Waite, Lindsay L, Harris, Tamara B, Smith, Albert Vernon, Shuldiner, Alan R, McArdle, Wendy L, Caulfield, Mark J, Munroe, Patricia B, Grönberg, Henrik, Chen, Yii-Der Ida, Li, Guo, Beckmann, Jacques S, Johnson, Toby, Thorsteinsdottir, Unnur, Teder-Laving, Maris, Khaw, Kay-Tee, Wareham, Nicholas J, Zhao, Jing Hua, Amin, Najaf, Oostra, Ben A, Kraja, Aldi T, Province, Michael A, Cupples, L Adrienne, Heard-Costa, Nancy L, Kaprio, Jaakko, Ripatti, Samuli, Surakka, Ida, Collins, Francis S, Saramies, Jouko, Tuomilehto, Jaakko, Jula, Antti, Salomaa, Veikko, Erdmann, Jeanette, Hengstenberg, Christian, Loley, Christina, Schunkert, Heribert, Lamina, Claudia, Wichmann, H Erich, Albrecht, Eva, Gieger, Christian, Hicks, Andrew A, Johansson, Asa, Pramstaller, Peter P, Kathiresan, Sekar, Speliotes, Elizabeth K, Penninx, Brenda, Hartikainen, Anna-Liisa, Jarvelin, Marjo-Riitta, Gyllensten, Ulf, Boomsma, Dorret I, Campbell, Harry, Wilson, James F, Chanock, Stephen J, Farrall, Martin, Goel, Anuj, Medina-Gomez, Carolina, Rivadeneira, Fernando, Estrada, Karol, Uitterlinden, André G, Hofman, Albert, Zillikens, M Carola
• Format: Article
• Language: English
• Subjects: Anthropometry - methods; Basale medisinske, odontologiske og veterinærmedisinske fag: 710; Basic medical, dental and veterinary science disciplines: 710; Body Height - genetics; Body Mass Index; Body Weight - genetics; Body Weights and Measures; Clinical Medicine; Community medicine, Social medicine: 801; Dimorphism (Biology); Endocrinology and Diabetes; Endokrinologi och diabetes; Epidemiologi; Female; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; Gene loci; Genetic Loci; Genome, Human; Genome-Wide Association Study; Genomics; Health sciences: 800; Helsefag: 800; Humans; Hälsovetenskap; Klinisk medicin; Male; Medical and Health Sciences; Medical disciplines: 700; Medical genetics: 714; Medical research; Medicin och hälsovetenskap; Medicine; Medicinsk genetik; Medicinska och farmaceutiska grundvetenskaper; Medisinsk genetikk: 714; Medisinske Fag: 700; Men; Polymorphism, Single Nucleotide; Quantitative genetics; Quantitative trait loci; Samfunnsmedisin, sosialmedisin: 801; Sex Characteristics; Studies; VDP; Waist Circumference - genetics; Waist-Hip Ratio
• ISSN: 1553-7404; 1553-7390; 1553-7404
• DOI: 10.1371/journal.pgen.1003500

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR