Cooperative binding

Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration....

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Bibliographic Details
Published in:PLoS computational biology 2013-06, Vol.9 (6), p.e1003106-e1003106
Main Authors: Stefan, Melanie I, Le Novère, Nicolas
Format: Article
Language:English
Subjects:
Binding Sites
Binding sites (Biochemistry)
Biology
Computational biology
Ligands
Ligands (Biochemistry)
Models, Molecular
Models, Theoretical
Molecular biology
Physiological aspects
Proteins
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Summary:Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration. This can be due, for instance, to an affinity for the ligand that depends on the amount of ligand bound. Cooperativity can be positive (supralinear) or negative (infralinear). Cooperative binding is most often observed in proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription factors. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes.
ISSN:1553-7358
1553-734X
1553-7358
DOI:10.1371/journal.pcbi.1003106