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Cooperative binding
Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration....
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| Published in: | PLoS computational biology 2013-06, Vol.9 (6), p.e1003106-e1003106 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c605t-6129c6f167a48aefeda5ea73394ff8d5b9fc33bf9a1b316863a52e0e1884664b3 |
| container_end_page | e1003106 |
| container_issue | 6 |
| container_start_page | e1003106 |
| container_title | PLoS computational biology |
| container_volume | 9 |
| creator | Stefan, Melanie I Le Novère, Nicolas |
| description | Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration. This can be due, for instance, to an affinity for the ligand that depends on the amount of ligand bound. Cooperativity can be positive (supralinear) or negative (infralinear). Cooperative binding is most often observed in proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription factors. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes. |
| doi_str_mv | 10.1371/journal.pcbi.1003106 |
| format | article |
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Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration. This can be due, for instance, to an affinity for the ligand that depends on the amount of ligand bound. Cooperativity can be positive (supralinear) or negative (infralinear). Cooperative binding is most often observed in proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription factors. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Stefan MI, Le Novère N (2013) Cooperative Binding. 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| identifier | ISSN: 1553-7358 |
| ispartof | PLoS computational biology, 2013-06, Vol.9 (6), p.e1003106-e1003106 |
| issn | 1553-7358 1553-734X 1553-7358 |
| language | eng |
| recordid | cdi_plos_journals_1427361559 |
| source | PubMed (Medline); Publicly Available Content Database |
| subjects | Binding Sites Binding sites (Biochemistry) Biology Computational biology Ligands Ligands (Biochemistry) Models, Molecular Models, Theoretical Molecular biology Physiological aspects Proteins Topic Page |
| title | Cooperative binding |
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