The spatial organization of DNA virus genomes in the nucleus

  PML NBs are also of substantial size (of the order of 1 µm diameter), but while the structures themselves have limited mobility, the component proteins undergo rapid exchange with the general nucleoplasm [6]. [...]an alternative explanation of viral genome-PML NB association is that it occurs not...

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Bibliographic Details
Published in:PLoS pathogens 2013-06, Vol.9 (6), p.e1003386-e1003386
Main Author: Everett, Roger D
Format: Article
Language:English
Subjects:
Animals
Binding sites
Biology
Cell Nucleus - virology
DNA damage
DNA Virus Infections - metabolism
DNA viruses
DNA Viruses - physiology
Gene expression
Genome, Viral - physiology
Genomes
Humans
Inclusion Bodies, Viral
Intranuclear Inclusion Bodies - metabolism
Intranuclear Inclusion Bodies - virology
Pearls
Physiological aspects
Proteins
Recruitment
Viral genetics
Virus Replication - physiology
Viruses
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Summary:  PML NBs are also of substantial size (of the order of 1 µm diameter), but while the structures themselves have limited mobility, the component proteins undergo rapid exchange with the general nucleoplasm [6]. [...]an alternative explanation of viral genome-PML NB association is that it occurs not because either entity migrates through the nucleoplasm, but because new PML NBs are formed at the sites of the viral genomes due to the deposition of PML NB protein molecules. [...]the current information is consistent with the hypothesis that entry of DNA virus genomes into the nucleus stimulates a cellular response that leads to the accumulation of PML NB proteins, and probably other restrictive proteins yet to be identified, in close association with the viral genomes.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003386