TCTP is an androgen-regulated gene implicated in prostate cancer

TCTP has been implicated in a plethora of important cellular processes related to cell growth, cell cycle progression, malignant transformation and inhibition of apoptosis. In addition to these intracellular functions, TCTP has extracellular functions and plays an important role in immune cells. TCT...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-07, Vol.8 (7), p.e69398
Main Authors: Kaarbø, Mari, Storm, Margrethe L, Qu, Su, Wæhre, Håkon, Risberg, Bjørn, Danielsen, Håvard E, Saatcioglu, Fahri
Format: Article
Language:English
Subjects:
Androgens
Androgens - pharmacology
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - genetics
B cells
Biology
Biomarkers, Tumor - deficiency
Biomarkers, Tumor - genetics
Biomarkers, Tumor - pharmacology
Cancer
Cancer genetics
Cell cycle
Cell growth
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Cell Survival - genetics
Cell Transformation, Neoplastic
Colonies
Deregulation
Development and progression
Gene expression
Gene Expression Regulation, Neoplastic - drug effects
Gene Knockdown Techniques
Genes
Genetic transformation
Humans
Immune response
Immune system
Interferon
Kinases
Male
Medicine
Mice
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - pathology
Prostate
Prostate cancer
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Recombinant Proteins - pharmacology
Rodents
Studies
Transformation
Tumor Protein, Translationally-Controlled 1
Xenografts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c716t-15c56e36f39211a92367c3f3ac474195a110ad3c1e5a116ed59be2f3dce48e453
cites cdi_FETCH-LOGICAL-c716t-15c56e36f39211a92367c3f3ac474195a110ad3c1e5a116ed59be2f3dce48e453
container_end_page
container_issue 7
container_start_page e69398
container_title PloS one
container_volume 8
creator Kaarbø, Mari
Storm, Margrethe L
Qu, Su
Wæhre, Håkon
Risberg, Bjørn
Danielsen, Håvard E
Saatcioglu, Fahri
description TCTP has been implicated in a plethora of important cellular processes related to cell growth, cell cycle progression, malignant transformation and inhibition of apoptosis. In addition to these intracellular functions, TCTP has extracellular functions and plays an important role in immune cells. TCTP expression was previously shown to be deregulated in prostate cancer, but its function in prostate cancer cells is largely unknown. Here we show that TCTP expression is regulated by androgens in LNCaP prostate cancer cells in vitro as well as human prostate cancer xenografts in vivo. Knockdown of TCTP reduced colony formation and increased apoptosis in LNCaP cells, implicating it as an important factor for prostate cancer cell growth. Global gene expression profiling in TCTP knockdown LNCaP cells showed that several interferon regulated genes are regulated by TCTP, suggesting that it may have a role in regulating immune function in prostate cancer. In addition, recombinant TCTP treatment increased colony formation in LNCaP cells suggesting that secreted TCTP may function as a proliferative factor in prostate cancer. These results suggest that TCTP may have a role in prostate cancer development.
doi_str_mv 10.1371/journal.pone.0069398
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1427370362</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478166972</galeid><doaj_id>oai_doaj_org_article_7465b91ddf134f039a18cf863abad9c1</doaj_id><sourcerecordid>A478166972</sourcerecordid><originalsourceid>FETCH-LOGICAL-c716t-15c56e36f39211a92367c3f3ac474195a110ad3c1e5a116ed59be2f3dce48e453</originalsourceid><addsrcrecordid>eNqNkl2L1DAUhoso7rr6D0QLguBFx5wmTZMbcRn8GFhY0dHbkEnTToZOUpNU9N-b2e2sU1CQFJKTPucj57xZ9hTQAnANr3du9Fb2i8FZvUCIcszZvewcOC4LWiJ8_-R8lj0KYYdQhRmlD7OzEjNOCOXn2dv1cv0pNyGXNn2Nd522hdfd2MuomzxZOjf7oTfqxjY2H7wLMRm5klZp_zh70Mo-6CfTfpF9ff9uvfxYXF1_WC0vrwpVA40FVKqiGtMW8xJA8hLTWuEWS0VqArySAEg2WIE-HKluKr7RZYsbpQnTpMIX2fPbuEPvgpgeHwSQssY1wrRMxOqWaJzcicGbvfS_hJNG3Fw43wnpo1G9FjWh1YZD07SASYswl8BUyyiWG9lwBSnWmynbuNnrVISNXvazoPM_1mxF536INBlGGf5TrvImRGOFdV4KQKwqRRoUsES8mFJ4933UIf7jURPVyVS3sa1L6dTeBCUuSc2AUl4fqMVfqLQavTcqCaQ16X7m8GrmkJiof8ZOjiGI1ZfP_89ef5uzL0_YrZZ93AbXj9E4G-YgOfbHheB1e9dbQOKg72M3xEHfYtJ3cnt2Opc7p6Og8W9sAfLE</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1427370362</pqid></control><display><type>article</type><title>TCTP is an androgen-regulated gene implicated in prostate cancer</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>NORA - Norwegian Open Research Archives</source><source>PubMed Central</source><creator>Kaarbø, Mari ; Storm, Margrethe L ; Qu, Su ; Wæhre, Håkon ; Risberg, Bjørn ; Danielsen, Håvard E ; Saatcioglu, Fahri</creator><contributor>Ling, Ming Tat</contributor><creatorcontrib>Kaarbø, Mari ; Storm, Margrethe L ; Qu, Su ; Wæhre, Håkon ; Risberg, Bjørn ; Danielsen, Håvard E ; Saatcioglu, Fahri ; Ling, Ming Tat</creatorcontrib><description>TCTP has been implicated in a plethora of important cellular processes related to cell growth, cell cycle progression, malignant transformation and inhibition of apoptosis. In addition to these intracellular functions, TCTP has extracellular functions and plays an important role in immune cells. TCTP expression was previously shown to be deregulated in prostate cancer, but its function in prostate cancer cells is largely unknown. Here we show that TCTP expression is regulated by androgens in LNCaP prostate cancer cells in vitro as well as human prostate cancer xenografts in vivo. Knockdown of TCTP reduced colony formation and increased apoptosis in LNCaP cells, implicating it as an important factor for prostate cancer cell growth. Global gene expression profiling in TCTP knockdown LNCaP cells showed that several interferon regulated genes are regulated by TCTP, suggesting that it may have a role in regulating immune function in prostate cancer. In addition, recombinant TCTP treatment increased colony formation in LNCaP cells suggesting that secreted TCTP may function as a proliferative factor in prostate cancer. These results suggest that TCTP may have a role in prostate cancer development.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0069398</identifier><identifier>PMID: 23894469</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Androgens ; Androgens - pharmacology ; Animals ; Apoptosis ; Apoptosis - drug effects ; Apoptosis - genetics ; B cells ; Biology ; Biomarkers, Tumor - deficiency ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - pharmacology ; Cancer ; Cancer genetics ; Cell cycle ; Cell growth ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Cell Survival - genetics ; Cell Transformation, Neoplastic ; Colonies ; Deregulation ; Development and progression ; Gene expression ; Gene Expression Regulation, Neoplastic - drug effects ; Gene Knockdown Techniques ; Genes ; Genetic transformation ; Humans ; Immune response ; Immune system ; Interferon ; Kinases ; Male ; Medicine ; Mice ; Neoplastic Stem Cells - drug effects ; Neoplastic Stem Cells - pathology ; Prostate ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; Recombinant Proteins - genetics ; Recombinant Proteins - metabolism ; Recombinant Proteins - pharmacology ; Rodents ; Studies ; Transformation ; Tumor Protein, Translationally-Controlled 1 ; Xenografts</subject><ispartof>PloS one, 2013-07, Vol.8 (7), p.e69398</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Kaarbø et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>2013 Kaarbø et al 2013 Kaarbø et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c716t-15c56e36f39211a92367c3f3ac474195a110ad3c1e5a116ed59be2f3dce48e453</citedby><cites>FETCH-LOGICAL-c716t-15c56e36f39211a92367c3f3ac474195a110ad3c1e5a116ed59be2f3dce48e453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1427370362/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1427370362?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,26567,27924,27925,37012,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23894469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ling, Ming Tat</contributor><creatorcontrib>Kaarbø, Mari</creatorcontrib><creatorcontrib>Storm, Margrethe L</creatorcontrib><creatorcontrib>Qu, Su</creatorcontrib><creatorcontrib>Wæhre, Håkon</creatorcontrib><creatorcontrib>Risberg, Bjørn</creatorcontrib><creatorcontrib>Danielsen, Håvard E</creatorcontrib><creatorcontrib>Saatcioglu, Fahri</creatorcontrib><title>TCTP is an androgen-regulated gene implicated in prostate cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>TCTP has been implicated in a plethora of important cellular processes related to cell growth, cell cycle progression, malignant transformation and inhibition of apoptosis. In addition to these intracellular functions, TCTP has extracellular functions and plays an important role in immune cells. TCTP expression was previously shown to be deregulated in prostate cancer, but its function in prostate cancer cells is largely unknown. Here we show that TCTP expression is regulated by androgens in LNCaP prostate cancer cells in vitro as well as human prostate cancer xenografts in vivo. Knockdown of TCTP reduced colony formation and increased apoptosis in LNCaP cells, implicating it as an important factor for prostate cancer cell growth. Global gene expression profiling in TCTP knockdown LNCaP cells showed that several interferon regulated genes are regulated by TCTP, suggesting that it may have a role in regulating immune function in prostate cancer. In addition, recombinant TCTP treatment increased colony formation in LNCaP cells suggesting that secreted TCTP may function as a proliferative factor in prostate cancer. These results suggest that TCTP may have a role in prostate cancer development.</description><subject>Androgens</subject><subject>Androgens - pharmacology</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - genetics</subject><subject>B cells</subject><subject>Biology</subject><subject>Biomarkers, Tumor - deficiency</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - pharmacology</subject><subject>Cancer</subject><subject>Cancer genetics</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - genetics</subject><subject>Cell Transformation, Neoplastic</subject><subject>Colonies</subject><subject>Deregulation</subject><subject>Development and progression</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Gene Knockdown Techniques</subject><subject>Genes</subject><subject>Genetic transformation</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Interferon</subject><subject>Kinases</subject><subject>Male</subject><subject>Medicine</subject><subject>Mice</subject><subject>Neoplastic Stem Cells - drug effects</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - metabolism</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Rodents</subject><subject>Studies</subject><subject>Transformation</subject><subject>Tumor Protein, Translationally-Controlled 1</subject><subject>Xenografts</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>3HK</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLguBFx5wmTZMbcRn8GFhY0dHbkEnTToZOUpNU9N-b2e2sU1CQFJKTPucj57xZ9hTQAnANr3du9Fb2i8FZvUCIcszZvewcOC4LWiJ8_-R8lj0KYYdQhRmlD7OzEjNOCOXn2dv1cv0pNyGXNn2Nd522hdfd2MuomzxZOjf7oTfqxjY2H7wLMRm5klZp_zh70Mo-6CfTfpF9ff9uvfxYXF1_WC0vrwpVA40FVKqiGtMW8xJA8hLTWuEWS0VqArySAEg2WIE-HKluKr7RZYsbpQnTpMIX2fPbuEPvgpgeHwSQssY1wrRMxOqWaJzcicGbvfS_hJNG3Fw43wnpo1G9FjWh1YZD07SASYswl8BUyyiWG9lwBSnWmynbuNnrVISNXvazoPM_1mxF536INBlGGf5TrvImRGOFdV4KQKwqRRoUsES8mFJ4933UIf7jURPVyVS3sa1L6dTeBCUuSc2AUl4fqMVfqLQavTcqCaQ16X7m8GrmkJiof8ZOjiGI1ZfP_89ef5uzL0_YrZZ93AbXj9E4G-YgOfbHheB1e9dbQOKg72M3xEHfYtJ3cnt2Opc7p6Og8W9sAfLE</recordid><startdate>20130722</startdate><enddate>20130722</enddate><creator>Kaarbø, Mari</creator><creator>Storm, Margrethe L</creator><creator>Qu, Su</creator><creator>Wæhre, Håkon</creator><creator>Risberg, Bjørn</creator><creator>Danielsen, Håvard E</creator><creator>Saatcioglu, Fahri</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>3HK</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130722</creationdate><title>TCTP is an androgen-regulated gene implicated in prostate cancer</title><author>Kaarbø, Mari ; Storm, Margrethe L ; Qu, Su ; Wæhre, Håkon ; Risberg, Bjørn ; Danielsen, Håvard E ; Saatcioglu, Fahri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c716t-15c56e36f39211a92367c3f3ac474195a110ad3c1e5a116ed59be2f3dce48e453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Androgens</topic><topic>Androgens - pharmacology</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - genetics</topic><topic>B cells</topic><topic>Biology</topic><topic>Biomarkers, Tumor - deficiency</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - pharmacology</topic><topic>Cancer</topic><topic>Cancer genetics</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - genetics</topic><topic>Cell Transformation, Neoplastic</topic><topic>Colonies</topic><topic>Deregulation</topic><topic>Development and progression</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Gene Knockdown Techniques</topic><topic>Genes</topic><topic>Genetic transformation</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Interferon</topic><topic>Kinases</topic><topic>Male</topic><topic>Medicine</topic><topic>Mice</topic><topic>Neoplastic Stem Cells - drug effects</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Recombinant Proteins - genetics</topic><topic>Recombinant Proteins - metabolism</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Rodents</topic><topic>Studies</topic><topic>Transformation</topic><topic>Tumor Protein, Translationally-Controlled 1</topic><topic>Xenografts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaarbø, Mari</creatorcontrib><creatorcontrib>Storm, Margrethe L</creatorcontrib><creatorcontrib>Qu, Su</creatorcontrib><creatorcontrib>Wæhre, Håkon</creatorcontrib><creatorcontrib>Risberg, Bjørn</creatorcontrib><creatorcontrib>Danielsen, Håvard E</creatorcontrib><creatorcontrib>Saatcioglu, Fahri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale_Opposing Viewpoints In Context</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest_Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Database‎ (1962 - current)</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaarbø, Mari</au><au>Storm, Margrethe L</au><au>Qu, Su</au><au>Wæhre, Håkon</au><au>Risberg, Bjørn</au><au>Danielsen, Håvard E</au><au>Saatcioglu, Fahri</au><au>Ling, Ming Tat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TCTP is an androgen-regulated gene implicated in prostate cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-07-22</date><risdate>2013</risdate><volume>8</volume><issue>7</issue><spage>e69398</spage><pages>e69398-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>TCTP has been implicated in a plethora of important cellular processes related to cell growth, cell cycle progression, malignant transformation and inhibition of apoptosis. In addition to these intracellular functions, TCTP has extracellular functions and plays an important role in immune cells. TCTP expression was previously shown to be deregulated in prostate cancer, but its function in prostate cancer cells is largely unknown. Here we show that TCTP expression is regulated by androgens in LNCaP prostate cancer cells in vitro as well as human prostate cancer xenografts in vivo. Knockdown of TCTP reduced colony formation and increased apoptosis in LNCaP cells, implicating it as an important factor for prostate cancer cell growth. Global gene expression profiling in TCTP knockdown LNCaP cells showed that several interferon regulated genes are regulated by TCTP, suggesting that it may have a role in regulating immune function in prostate cancer. In addition, recombinant TCTP treatment increased colony formation in LNCaP cells suggesting that secreted TCTP may function as a proliferative factor in prostate cancer. These results suggest that TCTP may have a role in prostate cancer development.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23894469</pmid><doi>10.1371/journal.pone.0069398</doi><tpages>e69398</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2013-07, Vol.8 (7), p.e69398
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1427370362
source Publicly Available Content Database (Proquest) (PQ_SDU_P3); NORA - Norwegian Open Research Archives; PubMed Central
subjects Androgens
Androgens - pharmacology
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - genetics
B cells
Biology
Biomarkers, Tumor - deficiency
Biomarkers, Tumor - genetics
Biomarkers, Tumor - pharmacology
Cancer
Cancer genetics
Cell cycle
Cell growth
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Cell Survival - genetics
Cell Transformation, Neoplastic
Colonies
Deregulation
Development and progression
Gene expression
Gene Expression Regulation, Neoplastic - drug effects
Gene Knockdown Techniques
Genes
Genetic transformation
Humans
Immune response
Immune system
Interferon
Kinases
Male
Medicine
Mice
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - pathology
Prostate
Prostate cancer
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Recombinant Proteins - pharmacology
Rodents
Studies
Transformation
Tumor Protein, Translationally-Controlled 1
Xenografts
title TCTP is an androgen-regulated gene implicated in prostate cancer
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T08%3A24%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TCTP%20is%20an%20androgen-regulated%20gene%20implicated%20in%20prostate%20cancer&rft.jtitle=PloS%20one&rft.au=Kaarb%C3%B8,%20Mari&rft.date=2013-07-22&rft.volume=8&rft.issue=7&rft.spage=e69398&rft.pages=e69398-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0069398&rft_dat=%3Cgale_plos_%3EA478166972%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c716t-15c56e36f39211a92367c3f3ac474195a110ad3c1e5a116ed59be2f3dce48e453%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1427370362&rft_id=info:pmid/23894469&rft_galeid=A478166972&rfr_iscdi=true