Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?

The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased per...

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Bibliographic Details
Published in:PloS one 2013-07, Vol.8 (7), p.e68294-e68294
Main Authors: van der Flier, Michiel, Sharma, Dyana B, Estevão, Silvia, Emonts, Marieke, Rook, Denise, Hazelzet, Jan A, van Goudoever, Johannes B, Hartwig, Nico G
Format: Article
Language:English
Subjects:
Adolescent
Antigens
Antigens, CD - blood
Antigens, CD - chemistry
Antigens, CD - metabolism
Apoptosis
Birth weight
Carcinoembryonic antigen
CD4 antigen
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
CD66 antigen
CEACAM1 protein
Cell Adhesion Molecules - blood
Cell Adhesion Molecules - chemistry
Cell Adhesion Molecules - metabolism
Child
Child, Preschool
Children
Consent
Female
Gene Expression Regulation - immunology
Humans
Immune Tolerance
Immunology
Infant
Infant, Low Birth Weight - blood
Infant, Low Birth Weight - immunology
Infant, Newborn
Infants
Infections
Infectious diseases
Inflammation
Intensive care
Laboratories
Ligands
Lymphocytes
Lymphocytes T
Male
Medical ethics
Meningitis
Meningococcal Infections - complications
Neisseria meningitidis
Neonates
Newborn babies
Pediatrics
Proteins
Sepsis
Sepsis - blood
Sepsis - complications
Sepsis - immunology
Sepsis - metabolism
Septic shock
Solubility
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Summary:The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased percentage CEACAM1 positive CD4(+) T-cells. Meningococcal septic shock in children was associated with increased serum soluble CEACAM1. In conclusion our data demonstrate increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis in VLBW-infants, and increased circulating soluble CEACAM1 in children with meningococcal sepsis. Increased T-cell CEACAM1 expression and increased circulating soluble CEACAM1 may contribute to sepsis-associated immune suppression.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0068294