The systemic immune network in recent onset type 1 diabetes: central role of interleukin-1 receptor antagonist (DIATOR Trial)

The hypothesis was tested that the systemic immune milieu in recent-onset type 1 diabetes is associated with residual beta cell function and other metabolic patient characteristics. All patients (n = 89, 40% female) of the Diabetes and Atorvastatin (DIATOR) Trial were analyzed at recruitment, i.e. p...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e72440-e72440
Main Authors: Kolb, Hubert, Lückemeyer, Kathrin, Heise, Tim, Herder, Christian, Schloot, Nanette C, Koenig, Wolfgang, Heinemann, Lutz, Martin, Stephan
Format: Article
Language:English
Subjects:
Acute phase proteins
Acute phase substances
Adhesion
Adolescent
Adult
Age
Atherosclerosis
Atorvastatin
Autoantibodies
Beta cells
Biology
Body mass
Chemokines
Correlation
Cytokines
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - immunology
Drugs
E-selectin
Fasting
Female
Humans
Inflammation
Insulin
Interleukin
Interleukin 1
Interleukin 1 receptor antagonist
Interleukin 1 Receptor Antagonist Protein - physiology
Interleukin 1 receptors
Interleukin 6
IP (Internet Protocol)
IP-10 protein
Islets of Langerhans - immunology
Lymphocytes T
Male
Medicine
Metabolic syndrome
Obesity
Patients
Peptides
Proteins
Recruitment
Rodents
Sex
Young Adult
γ-Interferon
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Summary:The hypothesis was tested that the systemic immune milieu in recent-onset type 1 diabetes is associated with residual beta cell function and other metabolic patient characteristics. All patients (n = 89, 40% female) of the Diabetes and Atorvastatin (DIATOR) Trial were analyzed at recruitment, i.e. prior to receiving the study medication. Inclusion criteria were insulin dependent diabetes for 2 weeks to 3 months, age range 18-39 years, and islet cell autoantibodies. Blood samples were analyzed for 14 immune mediators by standard methods. Concentrations of all mediators correlated with at least one other mediator (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0072440