Oxygen generating biomaterials preserve skeletal muscle homeostasis under hypoxic and ischemic conditions

Provision of supplemental oxygen to maintain soft tissue viability acutely following trauma in which vascularization has been compromised would be beneficial for limb and tissue salvage. For this application, an oxygen generating biomaterial that may be injected directly into the soft tissue could p...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e72485
Main Authors: Ward, Catherine L, Corona, Benjamin T, Yoo, James J, Harrison, Benjamin S, Christ, George J
Format: Article
Language:English
Subjects:
Animals
Bicarbonate
Bicarbonates
Biocompatibility
Biology
Biomaterials
Biomedical materials
Blood substitutes
Carbon dioxide
Carbonates
Chemistry
Contraction
Depletion
Fatigue
Fatigue tests
Female
Gangrene
Glycogen
Glycogen - metabolism
Homeostasis
Hydrogen
Hydrogen peroxide
Hypoxia
Hypoxia - physiopathology
In vivo methods and tests
Injuries
Ischemia
Ischemia - physiopathology
Lipid Peroxidation
Medicine
Metabolism
Muscle contraction
Muscle, Skeletal - blood supply
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiopathology
Muscles
Musculoskeletal system
Oxidative stress
Oxygen
Oxygen therapy
Perfluorocarbons
Peroxidation
Physiology
Rats, Inbred Lew
Rodents
Salvage
Skeletal muscle
Skin
Sodium
Sodium bicarbonate
Studies
Transplants & implants
Trauma
Vascularization
Viability
Wound healing
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Summary:Provision of supplemental oxygen to maintain soft tissue viability acutely following trauma in which vascularization has been compromised would be beneficial for limb and tissue salvage. For this application, an oxygen generating biomaterial that may be injected directly into the soft tissue could provide an unprecedented treatment in the acute trauma setting. The purpose of the current investigation was to determine if sodium percarbonate (SPO), an oxygen generating biomaterial, is capable of maintaining resting skeletal muscle homeostasis under otherwise hypoxic conditions. In the current studies, a biologically and physiologically compatible range of SPO (1-2 mg/mL) was shown to: 1) improve the maintenance of contractility and attenuate the accumulation of HIF1α, depletion of intramuscular glycogen, and oxidative stress (lipid peroxidation) that occurred following ∼30 minutes of hypoxia in primarily resting (duty cycle = 0.2 s train/120 s contraction interval
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0072485