Routine OGTT: a robust model including incretin effect for precise identification of insulin sensitivity and secretion in a single individual

In order to provide a method for precise identification of insulin sensitivity from clinical Oral Glucose Tolerance Test (OGTT) observations, a relatively simple mathematical model (Simple Interdependent glucose/insulin MOdel SIMO) for the OGTT, which coherently incorporates commonly accepted physio...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e70875-e70875
Main Authors: De Gaetano, Andrea, Panunzi, Simona, Matone, Alice, Samson, Adeline, Vrbikova, Jana, Bendlova, Bela, Pacini, Giovanni
Format: Article
Language:English
Subjects:
Adult
Algorithms
Biology
Blood glucose
Chromium
Coefficient of variation
Correlation analysis
Councils
Diabetes
Diabetes mellitus
Empirical analysis
Endocrinology
Female
Gastrointestinal tract
Glucose
Glucose - metabolism
Glucose Intolerance
Glucose tolerance
Glucose Tolerance Test - methods
Glucose Tolerance Test - standards
Homeostasis
Homeostasis - drug effects
Hormones
Humans
Identification
Incretins - pharmacology
Informatics
Insulin
Insulin - metabolism
Insulin Resistance
Insulin Secretion
Internet
Liver - metabolism
Male
Mathematical analysis
Mathematical models
Mathematics
Medicine
Metabolism
Methods
Middle Aged
Models, Theoretical
Parameter estimation
Physiological effects
Physiology
Reproducibility of Results
Robustness (mathematics)
Secretion
Sensitivity
Sensitivity and Specificity
Software
Studies
Systems analysis
Variance analysis
Young Adult
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Summary:In order to provide a method for precise identification of insulin sensitivity from clinical Oral Glucose Tolerance Test (OGTT) observations, a relatively simple mathematical model (Simple Interdependent glucose/insulin MOdel SIMO) for the OGTT, which coherently incorporates commonly accepted physiological assumptions (incretin effect and saturating glucose-driven insulin secretion) has been developed. OGTT data from 78 patients in five different glucose tolerance groups were analyzed: normal glucose tolerance (NGT), impaired glucose tolerance (IGT), impaired fasting glucose (IFG), IFG+IGT, and Type 2 Diabetes Mellitus (T2DM). A comparison with the 2011 Salinari (COntinuos GI tract MOdel, COMO) and the 2002 Dalla Man (Dalla Man MOdel, DMMO) models was made with particular attention to insulin sensitivity indices ISCOMO, ISDMMO and kxgi (the insulin sensitivity index for SIMO). ANOVA on kxgi values across groups resulted significant overall (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0070875