Early prefrontal brain responses to the Hedonic quality of emotional words--a simultaneous EEG and MEG study

• Published in: PloS one 2013-08, Vol.8 (8), p.e70788-e70788
• Main Authors: Keuper, Kati, Zwitserlood, Pienie, Rehbein, Maimu A, Eden, Annuschka S, Laeger, Inga, Junghöfer, Markus, Zwanzger, Peter, Dobel, Christian
• Format: Article
• Language: English
• Subjects: Adult; Arousal - physiology; Attention; Biology; Brain; Brain Mapping; Cognition & reasoning; Cognitive ability; Constraint modelling; Cortex (cingulate); Cortex (frontal); Cortex (occipital); Cortex (parietal); Cortex (temporal); EEG; Electroencephalography; Emotions; Emotions - physiology; Event-related potentials; Evoked Potentials; Female; Head; Hemispheric laterality; Humans; Hypotheses; Language; Language acquisition; Localization; Magnetoencephalography; Male; Medicine; Natural language processing; Neural networks; Neuroimaging; Neurons; Neurophysiology; Neurosciences; NMR; Nuclear magnetic resonance; Pattern recognition; Prefrontal cortex; Prefrontal Cortex - physiology; Psycholinguistics; Rapid serial visual presentation; Semantics; Statistical analysis; Studies; Temporal lobe; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0070788

The hedonic meaning of words affects word recognition, as shown by behavioral, functional imaging, and event-related potential (ERP) studies. However, the spatiotemporal dynamics and cognitive functions behind are elusive, partly due to methodological limitations of previous studies. Here, we account for these difficulties by computing combined electro-magnetoencephalographic (EEG/MEG) source localization techniques. Participants covertly read emotionally high-arousing positive and negative nouns, while EEG and MEG were recorded simultaneously. Combined EEG/MEG current-density reconstructions for the P1 (80-120 ms), P2 (150-190 ms) and EPN component (200-300 ms) were computed using realistic individual head models, with a cortical constraint. Relative to negative words, the P1 to positive words predominantly involved language-related structures (left middle temporal and inferior frontal regions), and posterior structures related to directed attention (occipital and parietal regions). Effects shifted to the right hemisphere in the P2 component. By contrast, negative words received more activation in the P1 time-range only, recruiting prefrontal regions, including the anterior cingulate cortex (ACC). Effects in the EPN were not statistically significant. These findings show that different neuronal networks are active when positive versus negative words are processed. We account for these effects in terms of an "emotional tagging" of word forms during language acquisition. These tags then give rise to different processing strategies, including enhanced lexical processing of positive words and a very fast language-independent alert response to negative words. The valence-specific recruitment of different networks might underlie fast adaptive responses to both approach- and withdrawal-related stimuli, be they acquired or biological.