Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor

Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, w...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e70533-e70533
Main Authors: Chu, Chih-Sheng, Wang, Yu-Chen, Lu, Long-Sheng, Walton, Brian, Yilmaz, H Ramazan, Huang, Roger Y, Sawamura, Tatsuya, Dixon, Richard A F, Lai, Wen-Ter, Chen, Chu-Huang, Lu, Jonathan
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Adult
Anticholesteremic Agents - therapeutic use
Antilipemic agents
Aorta
Atherogenesis
Atherosclerosis
Atorvastatin
Binding sites
Biology
C-reactive protein
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
Cardiology
Cardiovascular disease
Cell adhesion & migration
Cells, Cultured
Chemistry
Cholesterol
Coronary heart disease
Cysteine
Electronegativity
Endothelial cells
Endothelial Cells - metabolism
Endothelium
Female
Fibroblasts
Growth factors
Heart
Heptanoic Acids - therapeutic use
Hospitals
Humans
Hypercholesterolemia
Hypercholesterolemia - blood
Hypercholesterolemia - drug therapy
Hypercholesterolemia - metabolism
Internal medicine
Lectins
Lipids
Lipoproteins, LDL - blood
Lipoproteins, LDL - metabolism
Liquid oxygen
Low density lipoprotein
Low density lipoproteins
LOX-1 protein
Male
Medical research
Medicine
Microscopy
Middle Aged
Oxygen
Patients
Proteins
Pyrroles - therapeutic use
Reactive oxygen species
Reactive Oxygen Species - metabolism
Rodents
Scavenger Receptors, Class E - metabolism
Statins
Toxicity
Type 2 diabetes
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Summary:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1. Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0070533