Bilateral bi-cephalic tDCS with two active electrodes of the same polarity modulates bilateral cognitive processes differentially [corrected]

Transcranial direct current stimulation (tDCS) is an innovative method to explore the causal structure-function relationship of brain areas. We investigated the specificity of bilateral bi-cephalic tDCS with two active electrodes of the same polarity (e.g., cathodal on both hemispheres) applied to i...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e71607
Main Authors: Klein, Elise, Mann, Anne, Huber, Stefan, Bloechle, Johannes, Willmes, Klaus, Karim, Ahmed A, Nuerk, Hans-Christoph, Moeller, Korbinian
Format: Article
Language:English
Subjects:
Adult
Biology
Brain
Brain - physiology
Brain research
Cognition
Cognition & reasoning
Cognitive ability
Direct current
Electrical stimulation of the brain
Electrodes
Equipment Design
ESB
Familiarity
Female
Functional anatomy
Hemispheres
Humans
Interdisciplinary aspects
Knowledge
Male
Mathematical models
Medical imaging
Medicine
Natural language processing
Neuropsychology
NMR
Nuclear magnetic resonance
Polarity
Recruitment
Social and Behavioral Sciences
Stimulation
Structure-function relationships
Studies
Transcranial Magnetic Stimulation - instrumentation
Young Adult
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Summary:Transcranial direct current stimulation (tDCS) is an innovative method to explore the causal structure-function relationship of brain areas. We investigated the specificity of bilateral bi-cephalic tDCS with two active electrodes of the same polarity (e.g., cathodal on both hemispheres) applied to intraparietal cortices bilaterally using a combined between- and within-task approach. Regarding between-task specificity, we observed that bilateral bi-cephalic tDCS affected a numerical (mental addition) but not a control task (colour word Stroop), indicating a specific influence of tDCS on numerical but not on domain general cognitive processes associated with the bilateral IPS. In particular, the numerical effect of distractor distance was more pronounced under cathodal than under anodal stimulation. Moreover, with respect to within-task specificity we only found the numerical distractor distance effect in mental addition to be modulated by direct current stimulation, whereas the effect of target identity was not affected. This implies a differential influence of bilateral bi-cephalic tDCS on the recruitment of different processing components within the same task (number magnitude processing vs. recognition of familiarity). In sum, this first successful application of bilateral bi-cephalic tDCS with two active electrodes of the same polarity in numerical cognition research corroborates the specific proposition of the Triple Code Model that number magnitude information is represented bilaterally in the intraparietal cortices.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0071607