Efficacy and safety of anthelmintics tested against Taenia solium cysticercosis in pigs

Porcine cysticercosis, an infection caused by Taenia solium metacestodes, is continuously being reported in low-income countries of Latin America, Asia, and sub-Saharan Africa. The disease was declared eradicable by the International Task Force for Diseases Eradication (ITFDE) in 1993, and it is lis...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2013-07, Vol.7 (7), p.e2200
Main Authors: Mkupasi, Ernatus Martin, Sikasunge, Chummy Sikalizyo, Ngowi, Helena Aminiel, Johansen, Maria Vang
Format: Article
Language:English
Subjects:
Animals
Anthelmintics
Anthelmintics - administration & dosage
Anthelmintics - adverse effects
Care and treatment
Chemotherapy
Cysticercosis - drug therapy
Cysticercosis - veterinary
Cysts
Drug dosages
Drug-Related Side Effects and Adverse Reactions - epidemiology
Health aspects
Hogs
Infections
Medicine
Pork tapeworm
Review
Studies
Swine
Swine Diseases - drug therapy
Taenia solium - drug effects
Treatment Outcome
Veterinary Science
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Summary:Porcine cysticercosis, an infection caused by Taenia solium metacestodes, is continuously being reported in low-income countries of Latin America, Asia, and sub-Saharan Africa. The disease was declared eradicable by the International Task Force for Diseases Eradication (ITFDE) in 1993, and it is listed among the 17 WHO Neglected Tropical Diseases and Neglected Zoonoses that are potentially eradicable. In view of that, WHO has proposed a step-wise approach to its elimination, including chemotherapy of infected pigs. Different drugs have been tested on porcine cysticercosis with varying efficacies. These include flubendazole, fenbendazole, albendazole, albendazole sulphoxide, oxfendazole, praziquantel, and nitazoxanide. This review summarises available information on the efficacies and adverse effects shown by these drugs in pigs. Oxfendazole has shown to be effective for the control of porcine cysticercosis; however, it needs to be integrated with other control approaches. There is a need for standardised guidelines for evaluating the efficacy of anthelmintics against porcine cysticercosis, and more efficacy studies are needed since the conclusions so far are based on a limited number of studies using few infected pigs.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0002200