The TLR9 gene polymorphisms and the risk of cancer: evidence from a meta-analysis

Growing studies have revealed the association between polymorphisms in the Toll-like receptor 9 (TLR9) and susceptibility to cancer, however, the results remained inconsistent. To assess the effect of three selected SNPs (rs352140, rs5743836 and rs187084) in TLR9 on cancer, we performed a meta-analy...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e71785-e71785
Main Authors: Zhang, LuShun, Qin, HaoJie, Guan, Xuan, Zhang, Kui, Liu, ZhiRong
Format: Article
Language:English
Subjects:
Asian Continental Ancestry Group - genetics
Asthma
B cells
Biology
Cancer
Cancer genetics
Cancer research
Case-Control Studies
Confidence intervals
Disease susceptibility
Ethnicity
European Continental Ancestry Group - genetics
Forensic medicine
Gene Frequency
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Genotype
Health aspects
Health risks
Helicobacter pylori
Humans
Leukemia
Lymphoma
Mathematics
Medicine
Meta-analysis
Neoplasms - ethnology
Neoplasms - genetics
Odds Ratio
Polymorphism, Single Nucleotide
Quality
Risk
Risk Factors
Single-nucleotide polymorphism
Statistical analysis
Studies
TLR9 protein
Toll-Like Receptor 9 - genetics
Toll-like receptors
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Summary:Growing studies have revealed the association between polymorphisms in the Toll-like receptor 9 (TLR9) and susceptibility to cancer, however, the results remained inconsistent. To assess the effect of three selected SNPs (rs352140, rs5743836 and rs187084) in TLR9 on cancer, we performed a meta-analysis based on 11 case-control studies, including a total of 6,585 cancer cases and 7,506 controls. Summary odds ratios (OR) and corresponding 95% confidence intervals (CIs) for polymorphisms in TLR9 and cancer risk were estimated. Our meta-analysis indicated that rs352140 was associated with an increased cancer risk, especially in Caucasian. However, no significantly increased cancer risk was detected to be associated with rs187084 and rs5743836 either the overall or subgroup estimation. These meta-analysis results indicate that polymorphisms in TLR9 may play a role in cancer development.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0071785