Genome-wide association study reveals genetic architecture of eating behavior in pigs and its implications for humans obesity by comparative mapping

This study was aimed at identifying genomic regions controlling feeding behavior in Danish Duroc boars and its potential implications for eating behavior in humans. Data regarding individual daily feed intake (DFI), total daily time spent in feeder (TPD), number of daily visits to feeder (NVD), aver...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e71509-e71509
Main Authors: Do, Duy Ngoc, Strathe, Anders Bjerring, Ostersen, Tage, Jensen, Just, Mark, Thomas, Kadarmideen, Haja N
Format: Article
Language:English
Subjects:
Agriculture
Animal behavior
Animals
Biological effects
Biology
Breeding
Cattle
Chromosome Mapping
Chromosomes, Human - genetics
Chromosomes, Mammalian - genetics
Dephosphorylation
Development and progression
Eating
Eating behavior
Feed conversion
Feed efficiency
Feeding
Feeding Behavior
Feeds
Food habits
Gene expression
Gene mapping
Gene regulation
Genes
Genetic diversity
Genetic improvement
Genetic Markers
Genetic Predisposition to Disease
Genetic variance
Genome, Human - genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomics
Growth hormone-releasing hormone
Haplotypes - genetics
Human behavior
Humans
Kinases
Legal fees
Linkage Disequilibrium - genetics
Mapping
Medicine
Metabolic disorders
Metabolic syndrome
Molecular Sequence Annotation
Obesity
Obesity - genetics
Phenotype
Polymorphism, Single Nucleotide - genetics
Quality Control
Quantitative trait loci
Quantitative Trait Loci - genetics
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
Suidae
Sus scrofa - genetics
Swine
Synapses
Veterinary Science
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Summary:This study was aimed at identifying genomic regions controlling feeding behavior in Danish Duroc boars and its potential implications for eating behavior in humans. Data regarding individual daily feed intake (DFI), total daily time spent in feeder (TPD), number of daily visits to feeder (NVD), average duration of each visit (TPV), mean feed intake per visit (FPV) and mean feed intake rate (FR) were available for 1130 boars. All boars were genotyped using the Illumina Porcine SNP60 BeadChip. The association analyses were performed using the GenABEL package in the R program. Sixteen SNPs were found to have moderate genome-wide significance (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0071509