Tooth loss and risk of head and neck cancer: a meta-analysis

Observational studies suggest an association between tooth loss and risk of head and neck cancer. However, whether tooth loss is an independent risk factor for head and neck cancer still remains controversial. The aim of this study is to assess the association between tooth loss and head and neck ca...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8), p.e71122-e71122
Main Authors: Wang, Ren-Sheng, Hu, Xue-Ying, Gu, Wan-Jie, Hu, Zhen, Wei, Bo
Format: Article
Language:English
Subjects:
Alcohol
Bias
Cancer
Cancer research
Case-Control Studies
Confidence intervals
Cross-Sectional Studies
Disease
Gum disease
Head
Head & neck cancer
Head and neck cancer
Head and Neck Neoplasms - complications
Head and Neck Neoplasms - diagnosis
Health risks
Humans
Infections
Inflammation
Mathematics
Medicine
Meta-analysis
Odds Ratio
Oral hygiene
Population
Public health
Research Design
Risk analysis
Risk Factors
Sensitivity analysis
Studies
Teeth
Tooth loss
Tooth Loss - complications
Treatment Outcome
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Summary:Observational studies suggest an association between tooth loss and risk of head and neck cancer. However, whether tooth loss is an independent risk factor for head and neck cancer still remains controversial. The aim of this study is to assess the association between tooth loss and head and neck cancer risk. Eligible studies were searched in PubMed and Embase databases from their inception to March 2013. A random-effects model or fixed-effects model was used to calculate the overall combined risk estimates. Eight case-control studies and one cross-sectional study involving 5,204 patients and 5,518 controls were included in the meta-analysis. The overall combined odds ratio for tooth loss and head and neck cancer was 2.00 (95% confidence interval, 1.28-3.14). Similar results yielded both in the moderate and severe tooth loss group. Sensitivity analysis based on various exclusion criteria maintained this significance with respect to head and neck cancer individually. Little evidence of publication bias was observed. This meta-analysis suggests that tooth loss is associated with increased risk of head and neck cancer. This increase is probably independent of conventional head and neck cancer risk factors.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0071122