Association between circulating fibroblast growth factor 23, α-Klotho, and the left ventricular ejection fraction and left ventricular mass in cardiology inpatients

Fibroblast growth factor 23 (FGF23), with its co-receptor Klotho, plays a crucial role in phosphate metabolism. Several recent studies suggested that circulating FGF23 and α-Klotho concentrations might be related to cardiovascular abnormalities in patients with advanced renal failure. Using data fro...

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Bibliographic Details
Published in:PloS one 2013-09, Vol.8 (9), p.e73184-e73184
Main Authors: Shibata, Kensaku, Fujita, Shu-Ichi, Morita, Hideaki, Okamoto, Yusuke, Sohmiya, Koichi, Hoshiga, Masaaki, Ishizaka, Nobukazu
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Abnormalities
Aged
Aged, 80 and over
Calcium
Calcium metabolism
Calcium phosphates
Calcium Phosphates - blood
Cardiology
Cardiovascular disease
Dialysis
Enzymes
Ethics
Female
Fibroblast growth factor 23
Fibroblast Growth Factors - blood
Fibroblasts
Glomerular filtration rate
Glucuronidase - blood
Growth factors
Heart
Heart diseases
Heart Diseases - blood
Heart Diseases - diagnostic imaging
Heart Diseases - pathology
Heart Diseases - physiopathology
Heart Ventricles - diagnostic imaging
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Hemodialysis
Humans
Hypertrophy
Inpatients
Kidney diseases
Klotho protein
Laboratories
Male
Mathematical models
Metabolism
Middle Aged
Organ Size
Parathyroid
Parathyroid hormone
Phosphates
Population (statistical)
Proteins
Renal failure
Renal function
Rodents
Stroke Volume
Studies
Systematic review
Ultrasonography
Ventricle
Vitamin D
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Summary:Fibroblast growth factor 23 (FGF23), with its co-receptor Klotho, plays a crucial role in phosphate metabolism. Several recent studies suggested that circulating FGF23 and α-Klotho concentrations might be related to cardiovascular abnormalities in patients with advanced renal failure. Using data from 100 cardiology inpatients who were not undergoing chronic hemodialysis, the association of circulating levels of FGF23, α-Klotho, and other calcium-phosphate metabolism-related parameters with the left ventricular ejection fraction (LVEF) and left ventricular mass (LVM) was analyzed. LVEF was measured using the modified Simpson method for apical 4-chamber LV images and the LVM index (LVMI) was calculated by dividing the LVM by body surface area. Univariate analysis showed that log transformed FGF23, but not that of α-Klotho, was significantly associated with LVEF and LVMI with a standardized beta of -0.35 (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0073184