A randomized controlled study on the effects of bisoprolol and atenolol on sympathetic nervous activity and central aortic pressure in patients with essential hypertension

β-blockers (BBs) with different pharmacological properties may have heterogeneous effects on sympathetic nervous activity (SNA) and central aortic pressure (CAP), which are independent cardiovascular factors for hypertension. Hence, we analyzed the effects of bisoprolol and atenolol on SNA and CAP i...

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Bibliographic Details
Published in:PloS one 2013-09, Vol.8 (9), p.e72102
Main Authors: Zhou, Wei-Jun, Wang, Ren-Ying, Li, Yan, Chen, Dong-Rui, Chen, Er-Zhen, Zhu, Ding-Liang, Gao, Ping-Jin
Format: Article
Language:English
Subjects:
Adult
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Aorta
Arterial Pressure - drug effects
Atenolol
Atenolol - pharmacology
Atenolol - therapeutic use
Augmentation
Baroreceptors
Baroreflex - drug effects
Bisoprolol
Bisoprolol - pharmacology
Bisoprolol - therapeutic use
Blood pressure
Cardiovascular disease
Care and treatment
Drug dosages
Drugs
Essential Hypertension
Female
Genomics
Health sciences
Heart rate
Heart Rate - drug effects
Hemodynamics
Hospitals
Humans
Hypertension
Hypertension - drug therapy
Hypertension - physiopathology
Laboratories
Male
Medicine
Mercury
Middle Aged
Nervous system
Patient compliance
Patients
Pharmacology
Prospective Studies
Randomization
Reflexes
Spectral analysis
Statistical analysis
Treatment Outcome
Wave analysis
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Summary:β-blockers (BBs) with different pharmacological properties may have heterogeneous effects on sympathetic nervous activity (SNA) and central aortic pressure (CAP), which are independent cardiovascular factors for hypertension. Hence, we analyzed the effects of bisoprolol and atenolol on SNA and CAP in hypertensive patients. This was a prospective, randomized, controlled study in 109 never-treated hypertensive subjects randomized to bisoprolol (5 mg) or atenolol (50 mg) for 4-8 weeks. SNA, baroreflex sensitivity (BRS) and heart rate (HR) variability (HRV) were measured using power spectral analysis using a Finometer. CAP and related parameters were determined using the SphygmoCor device (pulse wave analysis). Both drugs were similarly effective in reducing brachial BP. However, central systolic BP (-14±10 mm Hg vs -6±9 mm Hg; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0072102