Prognostic significance of EDN/RB, HJURP, p60/CAF-1 and PDLI4, four new markers in high-grade gliomas

Recent studies have highlighted the heterogeneity of gliomas and demonstrated that molecular and genetic analysis could help in their classification and in the design of treatment protocols. In a previous study we have identified a 4-gene signature highly correlated with survival of glioma patients....

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Bibliographic Details
Published in:PloS one 2013-09, Vol.8 (9), p.e73332-e73332
Main Authors: de Tayrac, Marie, Saikali, Stephan, Aubry, Marc, Bellaud, Pascale, Boniface, Rachel, Quillien, Véronique, Mosser, Jean
Format: Article
Language:English
Subjects:
Analysis
Biomarkers
Biomarkers, Tumor - analysis
Brain - metabolism
Brain - pathology
Brain cancer
Brain Neoplasms - diagnosis
Brain Neoplasms - pathology
Brain tumors
Breast cancer
Chromatin Assembly Factor-1 - analysis
Classification
Criteria
DNA-Binding Proteins - analysis
Gene expression
Gene Expression Regulation, Neoplastic
Genetic analysis
Glioblastoma - diagnosis
Glioblastoma - pathology
Glioma
Glioma - diagnosis
Glioma - pathology
Gliomas
Heterogeneity
Histopathology
Humans
Immunohistochemistry
Life Sciences
LIM Domain Proteins - analysis
Medical diagnosis
Medical prognosis
Medical research
Multivariate analysis
Neoplasm Staging
Patients
Prognosis
Proteins
Quality
Receptor, Endothelin B
Receptors, Endothelin - analysis
Survival
Tumors
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Summary:Recent studies have highlighted the heterogeneity of gliomas and demonstrated that molecular and genetic analysis could help in their classification and in the design of treatment protocols. In a previous study we have identified a 4-gene signature highly correlated with survival of glioma patients. The aim of this study is to confirm and extend these findings by investigating the expression of these genes at the protein level and their association with outcome of patients with high grade gliomas. Immunohistochemical staining for EDN/RB, HJURP, p60/CAF-1 and PDLI4 was studied on archive materials from 96 patients (64 glioblastomas and 32 grade III gliomas). The levels of all four proteins differed significantly between grade III and grade IV tumours. The levels of the EDN/RB, HJURP and p60/CAF-1 proteins were strongly associated with overall survival (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0073332