Development of genomic resources for a thraustochytrid pathogen and investigation of temperature influences on gene expression

Understanding how environmental changes influence the pathogenicity and virulence of infectious agents is critical for predicting epidemiological patterns of disease. Thraustochytrids, part of the larger taxonomic class Labyrinthulomycetes, contain several highly pathogenic species, including the ha...

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Bibliographic Details
Published in:PloS one 2013-09, Vol.8 (9), p.e74196-e74196
Main Authors: Garcia-Vedrenne, Ana Elisa, Groner, Maya, Page-Karjian, Annie, Siegmund, Gregor-Fausto, Singhal, Sonia, Sziklay, Jamie, Roberts, Steven
Format: Article
Language:English
Subjects:
Animals
Annotations
Archives & records
Automation
Base Composition
Bioinformatics
Biological activity
Climate change
Computational Biology - methods
Environmental changes
Epidemiology
Fisheries
Gene expression
Gene Expression Regulation
Genes
Genome Size
Genome, Protozoan
Genomes
Genomics
Health aspects
Infectious diseases
Investigations
Life history
Marine biology
Mercenaria - genetics
Metabolism
Mollusks
Mortality
Ontology
Parasites
Pathogenicity
Pathogens
Physiology
Polymorphism, Single Nucleotide
Shellfish
Studies
Temperature
Temperature changes
Temperature effects
Temperature profiles
Transcriptome
Veterinary medicine
Virulence
Virulence (Microbiology)
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Summary:Understanding how environmental changes influence the pathogenicity and virulence of infectious agents is critical for predicting epidemiological patterns of disease. Thraustochytrids, part of the larger taxonomic class Labyrinthulomycetes, contain several highly pathogenic species, including the hard clam pathogen quahog parasite unknown (QPX). QPX has been associated with large-scale mortality events along the northeastern coast of North America. Growth and physiology of QPX is temperature-dependent, and changes in local temperature profiles influence pathogenicity. In this study we characterize the partial genome of QPX and examine the influence of temperature on gene expression. Genes involved in several biological processes are differentially expressed upon temperature change, including those associated with altered growth and metabolism and virulence. The genomic and transcriptomic resources developed in this study provide a foundation for better understanding virulence, pathogenicity and life history of thraustochytrid pathogens.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0074196