Reconstruction of the drive underlying food intake and its control by leptin and dieting

The intake of food and the expenditure of calories is modelled by a system of differential equations. The state variables are the amount of calories stored in adipose tissue and the level of plasma leptin. The model has as input a drive that controls the intake of food. This drive consists of a coll...

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Bibliographic Details
Published in:PloS one 2013-09, Vol.8 (9), p.e74997-e74997
Main Author: Grasman, Johan
Format: Article
Language:English
Subjects:
Adipose tissue
Adult
Body Weight - physiology
body-weight
Calories
Diet
Differential equations
Eating - physiology
Eating disorders
Endocrinology
Female
Food
Food intake
Humans
Incentives
kinetics
Leptin
Leptin - metabolism
Mathematical models
Metabolism
Nutrition
Obesity
patterns
Physiology
Rodents
Studies
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Summary:The intake of food and the expenditure of calories is modelled by a system of differential equations. The state variables are the amount of calories stored in adipose tissue and the level of plasma leptin. The model has as input a drive that controls the intake of food. This drive consists of a collective of physiological and psychological incentives to eat or to stop eating. An individual based approach is presented by which the parameters of the system can be set using data of a subject. The method of analysis is fully worked out using weight data of two persons. The model is prone to extensions by transferring incentives being part of the input to the collection of state variables.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0074997