Tuberculosis outcomes in Papua, Indonesia: the relationship with different body mass index characteristics between papuan and non-Papuan ethnic groups

• Published in: PloS one 2013-09, Vol.8 (9), p.e76077-e76077
• Main Authors: Kenangalem, Enny, Waramori, Govert, Pontororing, Gysje J, Sandjaja, Tjitra, Emiliana, Maguire, Graeme, Kelly, Paul M, Anstey, Nicholas M, Ralph, Anna P
• Format: Article
• Language: English
• Subjects: Adults; Body mass; Body Mass Index; Body size; Body weight gain; Clinical trials; Conversion; Culture; Diabetes; Drug dosages; Ethnicity; Hemoglobin; Hemoglobins - metabolism; Humans; Indonesia - epidemiology; Infectious diseases; Kaplan-Meier Estimate; Malnutrition; Medical diagnosis; Medical research; Microscopy; Minority & ethnic groups; Multivariable control; Mycobacterium tuberculosis; Preservation; Prospective Studies; Public health; Pulmonary functions; Quality; R&D; Research & development; Respiratory function; Respiratory Function Tests; Smear; Smoking; Sputum; Sputum - microbiology; Statistics, Nonparametric; Treatment Outcome; Tuberculosis; Tuberculosis - drug therapy; Tuberculosis - epidemiology; Tumor necrosis factor-TNF; Weight Gain - physiology
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0076077

Weight gain achieved during pulmonary tuberculosis (PTB) treatment is associated with the likelihood of bacteriological treatment success. It is recognised that weight and body mass index (BMI) characteristics differ between ethnic groups in health and illness states. However there has been no prior investigation of how ethnic differences in BMI might influence tuberculosis treatment outcome. Our aim was to investigate predictors of microbiological response to PTB treatment at the Tuberculosis Clinic in Timika, Papua Province, Indonesia and specifically, to determine the contribution of ethnicity. The population comprises two distinct ethnic groups - Asian (Non-Papuan) and Melanesian (Papuan). We conducted a prospective study of adults with smear-positive PTB. Treatment outcomes were 1- and 2-month sputum culture and time to microscopy conversion. Clinical measures included weight, BMI, chest radiograph, pulmonary function including forced expiratory volume in 1 second (FEV1) and haemoglobin. One hundred eighty six participants (83 Papuan, 103 non-Papuan Indonesians) were enrolled. At baseline, Papuans had higher mean weight and BMI than non-Papuans (50.0 kg versus 46.9 kg, p = 0.006 and 20.0 kg/m2 versus 18.7 kg/m2, p = 0.001 respectively). This was despite having lower mean haemoglobin (11.3 vs 13.1 g/dL, p