A two-stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling

The ability to assess brain tumor perfusion and abnormalities in the vascular structure in vivo could provide significant benefits in terms of lesion diagnosis and assessment of treatment response. Arterial spin labeling (ASL) has emerged as an increasingly viable methodology for non-invasive assess...

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Bibliographic Details
Published in:PloS one 2013-10, Vol.8 (10), p.e75717-e75717
Main Authors: Hales, Patrick W, Phipps, Kim P, Kaur, Ramneek, Clark, Christopher A
Format: Article
Language:English
Subjects:
Abnormalities
Adult
Biological markers
Biomarkers
Biophysics
Blood
Blood Circulation
Blood Vessels - pathology
Blood Vessels - physiopathology
Blood volume
Brain
Brain cancer
Brain Neoplasms - blood supply
Brain Neoplasms - diagnosis
Brain tumors
Child
Childrens health
Comparative analysis
Contrast agents
Data acquisition
Development and progression
Female
Flow velocity
Genetic aspects
Humans
Kinetics
Labeling
Labelling
Magnetic Resonance Angiography
Male
Models, Biological
NMR
Nuclear magnetic resonance
Perfusion
Permeability
Physiological aspects
Spin labeling
Spin Labels
Transit time
Tumors
Veins & arteries
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Summary:The ability to assess brain tumor perfusion and abnormalities in the vascular structure in vivo could provide significant benefits in terms of lesion diagnosis and assessment of treatment response. Arterial spin labeling (ASL) has emerged as an increasingly viable methodology for non-invasive assessment of perfusion. Although kinetic models have been developed to describe perfusion in healthy tissue, the dynamic behaviour of the ASL signal in the brain tumor environment has not been extensively studied. We show here that dynamic ASL data acquired in brain tumors displays an increased level of 'biphasic' behaviour, compared to that seen in healthy tissue. A new two-stage model is presented which more accurately describes this behaviour, and provides measurements of perfusion, pre-capillary blood volume fraction and transit time, and capillary bolus arrival time. These biomarkers offer a novel contrast in the tumor and surrounding tissue, and provide a means for measuring tumor perfusion and vascular structural abnormalities in a fully non-invasive manner.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0075717