Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii

Acinetobacter baumannii is an emerging opportunistic bacterium associated with nosocomial infections in intensive care units. The alarming increase in infections caused by A. baumannii is strongly associated with enhanced resistance to antibiotics, in particular carbapenems. This, together with the...

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Published in:PloS one 2013-10, Vol.8 (10), p.e77631-e77631
Main Authors: Moriel, Danilo G, Beatson, Scott A, Wurpel, Daniël J, Lipman, Jeffrey, Nimmo, Graeme R, Paterson, David L, Schembri, Mark A
Format: Article
Language:English
Subjects:
Acinetobacter
Acinetobacter baumannii
Acinetobacter baumannii - genetics
Acinetobacter baumannii - immunology
Acinetobacter Infections - immunology
Acinetobacter Infections - microbiology
Acinetobacter Infections - prevention & control
Analysis
Antibiotics
Antigens
Antigens, Bacterial - analysis
Antigens, Bacterial - immunology
Bacterial Outer Membrane Proteins - analysis
Bacterial Outer Membrane Proteins - immunology
Bacterial Vaccines - analysis
Bacterial Vaccines - immunology
Bioinformatics
Carbapenems
Cloning
Computer Simulation
Contamination
Cross infection
Drug resistance
Drug Resistance, Multiple, Bacterial
Epidemiology
Genome, Bacterial
Genomes
Genomics
Health aspects
Health care
Hospitals
Humans
Identification
Immunization
Infectious diseases
Intensive care
Intensive care units
Localization
Microbial drug resistance
Multidrug resistance
Multidrug resistant organisms
Nosocomial infection
Nosocomial infections
Proteins
Proteomics
Vaccines
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description Acinetobacter baumannii is an emerging opportunistic bacterium associated with nosocomial infections in intensive care units. The alarming increase in infections caused by A. baumannii is strongly associated with enhanced resistance to antibiotics, in particular carbapenems. This, together with the lack of a licensed vaccine, has translated into significant economic, logistic and health impacts to health care facilities. In this study, we combined reverse vaccinology and proteomics to identify surface-exposed and secreted antigens from A. baumannii. Using in silico prediction tools and comparative genome analysis in combination with in vitro proteomic approaches, we identified 42 antigens that could be used as potential vaccine targets. Considering the paucity of effective antibiotics available to treat multidrug-resistant A. baumannii infections, these vaccine targets may serve as a framework for the development of a broadly protective multi-component vaccine, an outcome that would have a major impact on the burden of A. baumannii infections in intensive care units across the globe.
doi_str_mv 10.1371/journal.pone.0077631
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subjects Acinetobacter
Acinetobacter baumannii
Acinetobacter baumannii - genetics
Acinetobacter baumannii - immunology
Acinetobacter Infections - immunology
Acinetobacter Infections - microbiology
Acinetobacter Infections - prevention & control
Analysis
Antibiotics
Antigens
Antigens, Bacterial - analysis
Antigens, Bacterial - immunology
Bacterial Outer Membrane Proteins - analysis
Bacterial Outer Membrane Proteins - immunology
Bacterial Vaccines - analysis
Bacterial Vaccines - immunology
Bioinformatics
Carbapenems
Cloning
Computer Simulation
Contamination
Cross infection
Drug resistance
Drug Resistance, Multiple, Bacterial
Epidemiology
Genome, Bacterial
Genomes
Genomics
Health aspects
Health care
Hospitals
Humans
Identification
Immunization
Infectious diseases
Intensive care
Intensive care units
Localization
Microbial drug resistance
Multidrug resistance
Multidrug resistant organisms
Nosocomial infection
Nosocomial infections
Proteins
Proteomics
Vaccines
title Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii
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