A key role of microRNA-29b for the suppression of colon cancer cell migration by American ginseng

Metastasis of colon cancer cells increases the risk of colon cancer mortality. We have recently shown that American ginseng prevents colon cancer, and a Hexane extract of American Ginseng (HAG) has particularly potent anti-inflammatory and anti-cancer properties. Dysregulated microRNA (miR) expressi...

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Bibliographic Details
Published in:PloS one 2013-10, Vol.8 (10), p.e75034-e75034
Main Authors: Poudyal, Deepak, Cui, Xiangli, Le, Phuong Mai, Hofseth, Anne B, Windust, Anthony, Nagarkatti, Mitzi, Nagarkatti, Prakash S, Schetter, Aaron J, Harris, Curtis C, Hofseth, Lorne J
Format: Article
Language:English
Subjects:
Angiogenesis
Anticancer properties
Cancer
Cell Line, Tumor
Cell migration
Cell Movement - drug effects
Cell Movement - genetics
Colon
Colon cancer
Colonic Neoplasms - genetics
Colorectal cancer
Gelatinase A
Gene expression
Ginseng
HCT116 Cells
Health aspects
Health risks
Humans
Inflammation
Laboratories
Matrix metalloproteinase
Matrix Metalloproteinase 2 - genetics
Matrix Metalloproteinase 2 - metabolism
Medical research
Metalloproteinase
Metastases
Metastasis
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Oncology, Experimental
Panax - chemistry
Panax quinquefolius
Pharmacy
Plant Extracts - pharmacology
Prevention
Prostate cancer
R&D
Research & development
Ribonucleic acid
RNA
Tumors
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Summary:Metastasis of colon cancer cells increases the risk of colon cancer mortality. We have recently shown that American ginseng prevents colon cancer, and a Hexane extract of American Ginseng (HAG) has particularly potent anti-inflammatory and anti-cancer properties. Dysregulated microRNA (miR) expression has been observed in several disease conditions including colon cancer. Using global miR expression profiling, we observed increased miR-29b in colon cancer cells following exposure to HAG. Since miR-29b plays a role in regulating the migration of cancer cells, we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 (MMP-2) thereby suppressing the migration of colon cancer cells. Results are consistent with this hypothesis. Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0075034