Cardiac complications associated with short-term mortality in schizophrenia patients hospitalized for pneumonia: a nationwide case-control study

Pneumonia is one of most prevalent infectious diseases worldwide and is associated with considerable mortality. In comparison to general population, schizophrenia patients hospitalized for pneumonia have poorer outcomes. We explored the risk factors of short-term mortality in this population because...

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Bibliographic Details
Published in:PloS one 2013-07, Vol.8 (7), p.e70142-e70142
Main Authors: Liao, Ya-Tang, Yang, Shu-Yu, Liu, Hsing-Cheng, Chen, Wei J, Chen, Chiao-Chicy, Hung, Yen-Ni, Kuo, Chian-Jue
Format: Article
Language:English
Subjects:
Adult
Antipsychotics
Arrhythmia
Biology
Cardiac arrhythmia
Case-Control Studies
Clozapine
Comorbidity
Complications
Confidentiality
Diabetes
Drugs
Epidemiology
Female
Health care
Heart
Heart diseases
Heart Diseases - epidemiology
Heart Diseases - etiology
Heart Diseases - mortality
Hospitalization
Hospitals
Humans
Hyperglycemia
Hypoglycemia
Illnesses
Incidence
Infectious diseases
Male
Medicine
Mental disorders
Middle Aged
Mortality
Nursing
Older people
Patients
Pharmacy
Pneumonia
Pneumonia - complications
Pneumonia - drug therapy
Population
Prevalence
Preventive medicine
Psychiatry
Psychotropic drugs
Public health
Risk analysis
Risk Factors
Schizophrenia
Schizophrenia - complications
Schizophrenia - drug therapy
Short term
Studies
Systematic review
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Summary:Pneumonia is one of most prevalent infectious diseases worldwide and is associated with considerable mortality. In comparison to general population, schizophrenia patients hospitalized for pneumonia have poorer outcomes. We explored the risk factors of short-term mortality in this population because the information is lacking in the literature. In a nationwide schizophrenia cohort, derived from the National Health Insurance Research Database in Taiwan, that was hospitalized for pneumonia between 2000 and 2008 (n = 1,741), we identified 141 subjects who died during their hospitalizations or shortly after their discharges. Based on risk-set sampling in a 1∶4 ratio, 468 matched controls were selected from the study cohort (i.e., schizophrenia cohort with pneumonia). Physical illnesses were categorized as pre-existing and incident illnesses that developed after pneumonia respectively. Exposures to medications were categorized by type, duration, and defined daily dose. We used stepwise conditional logistic regression to explore the risk factors for short-term mortality. Pre-existing arrhythmia was associated with short-term mortality (adjusted risk ratio [RR] = 4.99, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0070142