Vitamin B12 and progression of white matter lesions. A 2-year follow-up study in first-ever lacunar stroke patients

In cross-sectional studies periventricular white matter lesions (WML) were related to low plasma levels of vitamin B12. Whether low vitamin B12 levels are also related to progression of WML is still unknown. We studied baseline vitamin B12 levels and its association with progression of WML over 2 ye...

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Published in:PloS one 2013-10, Vol.8 (10), p.e78100-e78100
Main Authors: van Overbeek, Ellen C, Staals, Julie, van Oostenbrugge, Robert J
Format: Article
Language:English
Subjects:
Age
Aged
Blood-brain barrier
Brain
Brain - pathology
Brain research
Cerebral Ventricles - pathology
Cyanocobalamin
Diabetes
Disease Progression
Family medical history
Female
Follow-Up Studies
Homocysteine
Humans
Hypertension
Lesions
Logistic Models
Magnetic resonance imaging
Male
Medical research
Middle Aged
Neurology
NMR
Nuclear magnetic resonance
Patients
Plasma levels
Prevention
Regression analysis
Statistical analysis
Stroke
Stroke patients
Stroke, Lacunar - blood
Stroke, Lacunar - pathology
Substantia alba
Supplementation
Supplements
Vitamin B 12 - blood
Vitamin B12
Vitamin deficiency
Vitamins
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van Oostenbrugge, Robert J
description In cross-sectional studies periventricular white matter lesions (WML) were related to low plasma levels of vitamin B12. Whether low vitamin B12 levels are also related to progression of WML is still unknown. We studied baseline vitamin B12 levels and its association with progression of WML over 2 years of follow-up in first-ever lacunar stroke patients. In 107 first-ever lacunar stroke patients in whom baseline brain MRI and vitamin B12 status were available, we obtained a follow-up brain MRI after 2 years. We assessed progression of periventricular WML (pWML) and deep WML (dWML) using a visual WML change scale. We studied the relationship between baseline levels of plasma vitamin B12 and progression of WML after 2 years of follow-up by binary logistic regression analyses. Vitamin B12 deficiency was more frequent in patients with progression of pWML compared to those without progression (41.9% and 19.7% respectively, p = 0.02). Corrected for sex and age, progression of pWML was associated with lower baseline levels of vitamin B12 (OR 1.42 per 50 unit decrease, 95% CI 1.00-1.92). Vitamin B12 levels were not associated with progression of dWML. In conclusion progression of pWML after 2 years of follow-up relates to low levels of vitamin B12 at baseline in first-ever lacunar stroke patients. Whether this population could benefit from vitamin B12 supplementation is unknown and requires further investigation.
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We assessed progression of periventricular WML (pWML) and deep WML (dWML) using a visual WML change scale. We studied the relationship between baseline levels of plasma vitamin B12 and progression of WML after 2 years of follow-up by binary logistic regression analyses. Vitamin B12 deficiency was more frequent in patients with progression of pWML compared to those without progression (41.9% and 19.7% respectively, p = 0.02). Corrected for sex and age, progression of pWML was associated with lower baseline levels of vitamin B12 (OR 1.42 per 50 unit decrease, 95% CI 1.00-1.92). Vitamin B12 levels were not associated with progression of dWML. In conclusion progression of pWML after 2 years of follow-up relates to low levels of vitamin B12 at baseline in first-ever lacunar stroke patients. 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A 2-year follow-up study in first-ever lacunar stroke patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-10-14</date><risdate>2013</risdate><volume>8</volume><issue>10</issue><spage>e78100</spage><epage>e78100</epage><pages>e78100-e78100</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In cross-sectional studies periventricular white matter lesions (WML) were related to low plasma levels of vitamin B12. Whether low vitamin B12 levels are also related to progression of WML is still unknown. We studied baseline vitamin B12 levels and its association with progression of WML over 2 years of follow-up in first-ever lacunar stroke patients. In 107 first-ever lacunar stroke patients in whom baseline brain MRI and vitamin B12 status were available, we obtained a follow-up brain MRI after 2 years. We assessed progression of periventricular WML (pWML) and deep WML (dWML) using a visual WML change scale. We studied the relationship between baseline levels of plasma vitamin B12 and progression of WML after 2 years of follow-up by binary logistic regression analyses. Vitamin B12 deficiency was more frequent in patients with progression of pWML compared to those without progression (41.9% and 19.7% respectively, p = 0.02). Corrected for sex and age, progression of pWML was associated with lower baseline levels of vitamin B12 (OR 1.42 per 50 unit decrease, 95% CI 1.00-1.92). Vitamin B12 levels were not associated with progression of dWML. In conclusion progression of pWML after 2 years of follow-up relates to low levels of vitamin B12 at baseline in first-ever lacunar stroke patients. Whether this population could benefit from vitamin B12 supplementation is unknown and requires further investigation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24155983</pmid><doi>10.1371/journal.pone.0078100</doi><oa>free_for_read</oa></addata></record>
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1932-6203
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subjects Age
Aged
Blood-brain barrier
Brain
Brain - pathology
Brain research
Cerebral Ventricles - pathology
Cyanocobalamin
Diabetes
Disease Progression
Family medical history
Female
Follow-Up Studies
Homocysteine
Humans
Hypertension
Lesions
Logistic Models
Magnetic resonance imaging
Male
Medical research
Middle Aged
Neurology
NMR
Nuclear magnetic resonance
Patients
Plasma levels
Prevention
Regression analysis
Statistical analysis
Stroke
Stroke patients
Stroke, Lacunar - blood
Stroke, Lacunar - pathology
Substantia alba
Supplementation
Supplements
Vitamin B 12 - blood
Vitamin B12
Vitamin deficiency
Vitamins
title Vitamin B12 and progression of white matter lesions. A 2-year follow-up study in first-ever lacunar stroke patients
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