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Cell-type specific features of circular RNA expression

Thousands of loci in the human and mouse genomes give rise to circular RNA transcripts; at many of these loci, the predominant RNA isoform is a circle. Using an improved computational approach for circular RNA identification, we found widespread circular RNA expression in Drosophila melanogaster and...

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Published in:	PLoS genetics 2013-09, Vol.9 (9), p.e1003777-e1003777
Main Authors:	Salzman, Julia, Chen, Raymond E, Olsen, Mari N, Wang, Peter L, Brown, Patrick O
Format:	Article
Language:	English
Subjects:	Animals Cell Lineage Drosophila melanogaster - genetics Exons - genetics Gene expression Gene Expression Regulation Humans Insects Mice Poly A - genetics Protein Isoforms - genetics Quantitative genetics RNA - biosynthesis RNA - genetics RNA sequencing RNA Splicing - genetics RNA, Circular RNA, Messenger - genetics Sequence Analysis, RNA Studies Transcription, Genetic
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description	Thousands of loci in the human and mouse genomes give rise to circular RNA transcripts; at many of these loci, the predominant RNA isoform is a circle. Using an improved computational approach for circular RNA identification, we found widespread circular RNA expression in Drosophila melanogaster and estimate that in humans, circular RNA may account for 1% as many molecules as poly(A) RNA. Analysis of data from the ENCODE consortium revealed that the repertoire of genes expressing circular RNA, the ratio of circular to linear transcripts for each gene, and even the pattern of splice isoforms of circular RNAs from each gene were cell-type specific. These results suggest that biogenesis of circular RNA is an integral, conserved, and regulated feature of the gene expression program.
doi_str_mv	10.1371/journal.pgen.1003777
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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO (2013) Cell-Type Specific Features of Circular RNA Expression. 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subjects	Animals Cell Lineage Drosophila melanogaster - genetics Exons - genetics Gene expression Gene Expression Regulation Humans Insects Mice Poly A - genetics Protein Isoforms - genetics Quantitative genetics RNA - biosynthesis RNA - genetics RNA sequencing RNA Splicing - genetics RNA, Circular RNA, Messenger - genetics Sequence Analysis, RNA Studies Transcription, Genetic
title	Cell-type specific features of circular RNA expression
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