Chronic restraint stress upregulates erythropoiesis through glucocorticoid stimulation

In response to elevated glucocorticoid levels, erythroid progenitors rapidly expand to produce large numbers of young erythrocytes. Previous work demonstrates hematopoietic changes in rodents exposed to various physical and psychological stressors, however, the effects of chronic psychological stres...

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Published in:PloS one 2013-10, Vol.8 (10), p.e77935-e77935
Main Authors: Voorhees, Jeffrey L, Powell, Nicole D, Moldovan, Leni, Mo, Xiaokui, Eubank, Timothy D, Marsh, Clay B
Format: Article
Language:English
Subjects:
Analysis
Animal models
Animal tissues
Animals
Biomarkers - metabolism
Blood
Blotting, Western
Cells, Cultured
Chronic Disease
Critical care
Erythrocytes
Erythrocytes - cytology
Erythrocytes - drug effects
Erythrocytes - metabolism
Erythroid Precursor Cells - cytology
Erythroid Precursor Cells - drug effects
Erythroid Precursor Cells - metabolism
Erythropoiesis
Erythropoiesis - drug effects
Erythropoiesis - physiology
Exposure
Female
Females
Gene expression
Gene Expression Profiling
Genomic analysis
Glucocorticoids
Glucocorticoids - metabolism
Heart
Hematology
Hemopoiesis
Homeostasis
Hormone Antagonists - pharmacology
Internal medicine
Iron
Laboratories
Medicine
Mental depression
Mice
Mice, Inbred C57BL
Mifepristone - pharmacology
Oligonucleotide Array Sequence Analysis
Psychological aspects
Psychological stress
Real-Time Polymerase Chain Reaction
Receptors, Glucocorticoid - antagonists & inhibitors
Restraint, Physical
Reticulocytes
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
Rodents
Steroids (Organic compounds)
Stimulation
Stress (Psychology)
Stress, Psychological - physiopathology
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cited_by cdi_FETCH-LOGICAL-c758t-355bca6884a3ddbd85babe1e790702baccf7c580eebeb84c0aa8c4f4f47407e63
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container_issue 10
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creator Voorhees, Jeffrey L
Powell, Nicole D
Moldovan, Leni
Mo, Xiaokui
Eubank, Timothy D
Marsh, Clay B
description In response to elevated glucocorticoid levels, erythroid progenitors rapidly expand to produce large numbers of young erythrocytes. Previous work demonstrates hematopoietic changes in rodents exposed to various physical and psychological stressors, however, the effects of chronic psychological stress on erythropoiesis has not be delineated. We employed laboratory, clinical and genomic analyses of a murine model of chronic restraint stress (RST) to examine the influence of psychological stress on erythropoiesis. Mice exposed to RST demonstrated markers of early erythroid expansion involving the glucocorticoid receptor. In addition, these RST-exposed mice had increased numbers of circulating reticulocytes and increased erythropoiesis in primary and secondary erythroid tissues. Mice also showed increases in erythroid progenitor populations and elevated expression of the erythroid transcription factor KLF1 in these cells. Together this work reports some of the first evidence of psychological stress affecting erythroid homeostasis through glucocorticoid stimulation.
doi_str_mv 10.1371/journal.pone.0077935
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identifier ISSN: 1932-6203
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language eng
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source Publicly Available Content Database; PubMed Central
subjects Analysis
Animal models
Animal tissues
Animals
Biomarkers - metabolism
Blood
Blotting, Western
Cells, Cultured
Chronic Disease
Critical care
Erythrocytes
Erythrocytes - cytology
Erythrocytes - drug effects
Erythrocytes - metabolism
Erythroid Precursor Cells - cytology
Erythroid Precursor Cells - drug effects
Erythroid Precursor Cells - metabolism
Erythropoiesis
Erythropoiesis - drug effects
Erythropoiesis - physiology
Exposure
Female
Females
Gene expression
Gene Expression Profiling
Genomic analysis
Glucocorticoids
Glucocorticoids - metabolism
Heart
Hematology
Hemopoiesis
Homeostasis
Hormone Antagonists - pharmacology
Internal medicine
Iron
Laboratories
Medicine
Mental depression
Mice
Mice, Inbred C57BL
Mifepristone - pharmacology
Oligonucleotide Array Sequence Analysis
Psychological aspects
Psychological stress
Real-Time Polymerase Chain Reaction
Receptors, Glucocorticoid - antagonists & inhibitors
Restraint, Physical
Reticulocytes
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
Rodents
Steroids (Organic compounds)
Stimulation
Stress (Psychology)
Stress, Psychological - physiopathology
title Chronic restraint stress upregulates erythropoiesis through glucocorticoid stimulation
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