Heart rate responses to autonomic challenges in obstructive sleep apnea

Obstructive sleep apnea (OSA) is accompanied by structural alterations and dysfunction in central autonomic regulatory regions, which may impair dynamic and static cardiovascular regulation, and contribute to other syndrome pathologies. Characterizing cardiovascular responses to autonomic challenges...

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Bibliographic Details
Published in:PloS one 2013-10, Vol.8 (10), p.e76631-e76631
Main Authors: Macey, Paul M, Kumar, Rajesh, Woo, Mary A, Yan-Go, Frisca L, Harper, Ronald M
Format: Article
Language:English
Subjects:
Analysis of Variance
Anxiety
Apnea
Autonomic nervous system
Autonomic Nervous System - physiology
Blood pressure
Brain research
Cardiovascular system
Central nervous system
Cold pressing
Delay
Female
Females
Gender differences
Hand Strength - physiology
Heart rate
Heart Rate - physiology
Humans
Male
Males
Medical research
Medicine
Middle Aged
Muscle contraction
Nervous system
Neurobiology
Neurosciences
Neurosurgery
Nursing schools
Oximetry
Patients
Regulatory sequences
Sex Characteristics
Sexually transmitted diseases
Sleep
Sleep apnea
Sleep Apnea, Obstructive - physiopathology
Sleep disorders
STD
Valsalva Maneuver - physiology
Variance analysis
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Summary:Obstructive sleep apnea (OSA) is accompanied by structural alterations and dysfunction in central autonomic regulatory regions, which may impair dynamic and static cardiovascular regulation, and contribute to other syndrome pathologies. Characterizing cardiovascular responses to autonomic challenges may provide insights into central nervous system impairments, including contributions by sex, since structural alterations are enhanced in OSA females over males. The objective was to assess heart rate responses in OSA versus healthy control subjects to autonomic challenges, and, separately, characterize female and male patterns. We studied 94 subjects, including 37 newly-diagnosed, untreated OSA patients (6 female, age mean ± std: 52.1 ± 8.1 years; 31 male aged 54.3 ± 8.4 years), and 57 healthy control subjects (20 female, 50.5 ± 8.1 years; 37 male, 45.6 ± 9.2 years). We measured instantaneous heart rate with pulse oximetry during cold pressor, hand grip, and Valsalva maneuver challenges. All challenges elicited significant heart rate differences between OSA and control groups during and after challenges (repeated measures ANOVA, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0076631