Skeletal muscle fascicle arrangements can be reconstructed using a Laplacian vector field simulation

• Published in: PloS one 2013-10, Vol.8 (10), p.e77576-e77576
• Main Authors: Choi, Hon Fai, Blemker, Silvia S
• Format: Article
• Language: English
• Subjects: Aerospace engineering; Architectural engineering; Boundary conditions; Computer applications; Computer Simulation; Contraction; Divergence; Finite element method; Geometry; Humans; Interpolation; Laplace equation; Mathematical models; Mechanics; Medical imaging; Methods; Morphology; Muscle contraction; Muscle Fibers, Skeletal - physiology; Muscles; Musculoskeletal system; NMR; Nuclear magnetic resonance; Partial differential equations; Physical characteristics; Physical properties; Representations; Robustness (mathematics); Skeletal muscle; Three dimensional models; Tibia - physiology; Tibialis anterior muscle; Trajectories
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0077576

Skeletal muscles are characterized by a large diversity in anatomical architecture and function. Muscle force and contraction are generated by contractile fiber cells grouped in fascicle bundles, which transmit the mechanical action between origin and insertion attachments of the muscle. Therefore, an adequate representation of fascicle arrangements in computational models of skeletal muscles is important, especially when investigating three-dimensional muscle deformations in finite element models. However, obtaining high resolution in vivo measurements of fascicle arrangements in skeletal muscles is currently still challenging. This motivated the development of methods in previous studies to generate numerical representations of fascicle trajectories using interpolation templates. Here, we present an alternative approach based on the hypothesis of a rotation and divergence free (Laplacian) vector field behavior which reflects observed physical characteristics of fascicle trajectories. To obtain this representation, the Laplace equation was solved in anatomical reconstructions of skeletal muscle shapes based on medical images using a uniform flux boundary condition on the attachment areas. Fascicle tracts were generated through a robust flux based tracing algorithm. The concept of this approach was demonstrated in two-dimensional synthetic examples of typical skeletal muscle architectures. A detailed evaluation was performed in an example of the anatomical human tibialis anterior muscle which showed an overall agreement with measurements from the literature. The utility and capability of the proposed method was further demonstrated in other anatomical examples of human skeletal muscles with a wide range of muscle shapes and attachment morphologies.