Analysis of factors contributing to the low survival of cervical cancer patients undergoing radiotherapy in Kenya

In contrast to the developed nations, invasive cervical cancer (ICC) is the most common womens malignancy in Kenya and many other locations in sub-Saharan Africa. However, studies on survival from this disease in this area of the world are severely restricted by lack of patient follow-up. We now rep...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-10, Vol.8 (10), p.e78411
Main Authors: Maranga, Innocent O, Hampson, Lynne, Oliver, Anthony W, Gamal, Anas, Gichangi, Peter, Opiyo, Anselmy, Holland, Catharine M, Hampson, Ian N
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
Aged
Aged, 80 and over
AIDS
Brachytherapy
Brachytherapy - methods
Cancer
Cancer therapies
Cervical cancer
Cervix
Chemotherapy
Chemotherapy, Adjuvant - methods
Demographics
Demography
Female
HIV
Human immunodeficiency virus
Humans
Invasiveness
Kenya
Lost to Follow-Up
Malignancy
Medical diagnosis
Middle Aged
Patients
Poverty
Prospective Studies
Radiation
Radiation therapy
Radiotherapy - methods
Radiotherapy Dosage
Survival
Survival Rate
Tumors
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - radiotherapy
Womens health
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In contrast to the developed nations, invasive cervical cancer (ICC) is the most common womens malignancy in Kenya and many other locations in sub-Saharan Africa. However, studies on survival from this disease in this area of the world are severely restricted by lack of patient follow-up. We now report a prospective cohort study of ICC in Kenyan women analysing factors affecting tumour response and overall survival in patients undergoing radiotherapy. Between 2008 and 2010, 355 patients with histologically confirmed ICC were recruited at the Departments of Gynaecology and Radiotherapy at Kenyatta National Hospital (KNH). Structured questionnaires were completed recording socio-demographics, tumour response and overall survival following treatment with combinations of external beam radiation (EBRT), brachytherapy and adjuvant chemotherapy. Of the 355 patients, 42% (146) were lost to follow-up while 18% (64) died during the two year period. 80.5% of patients presented with advanced stage IIB disease or above, with only 6.7% of patients receiving optimal combined EBRT, brachytherapy and adjuvant chemotherapy. Kaplan Meier survival curves projected two year survival at
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0078411