Serum uric acid and chronic kidney disease: the role of hypertension

There are inconsistent findings on the role of hyperuricemia as an independent risk factor for chronic kidney disease (CKD). Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD. In this population-based study we investigated the association betwee...

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Bibliographic Details
Published in:PloS one 2013-11, Vol.8 (11), p.e76827-e76827
Main Authors: Sedaghat, Sanaz, Hoorn, Ewout J, van Rooij, Frank J A, Hofman, Albert, Franco, Oscar H, Witteman, Jacqueline C M, Dehghan, Abbas
Format: Article
Language:English
Subjects:
Acids
Aged
Aged, 80 and over
Alcohol use
Analysis
Chronic kidney failure
Cohort Studies
Confidence intervals
Demographics
Diabetes
Epidermal growth factor receptors
Female
Glomerular Filtration Rate
Health risk assessment
Health risks
Humans
Hypertension
Hypertension - etiology
Hyperuricemia
Incidence
Kidney diseases
Kidneys
Kinases
Male
Medical research
Meta-analysis
Middle Aged
Mortality
Population studies
Population Surveillance
Renal function
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - physiopathology
Risk Factors
Studies
Uric acid
Uric Acid - blood
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Summary:There are inconsistent findings on the role of hyperuricemia as an independent risk factor for chronic kidney disease (CKD). Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD. In this population-based study we investigated the association between serum uric acid and decline in renal function and tested whether hypertension moderates this association. We included 2601 subjects aged 55 years and over from the Rotterdam Study. Serum uric acid and estimated glomerular filtration rate (eGFR) were assessed at baseline. After average 6.5 years of follow-up, second eGFR was assessed. CKD was defined as eGFR
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0076827